Milk Vs Wheat Protein Intake to Maximize Whole-body Protein Synthesis Rates in Healthy Older Adults

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-03-01

Study Completion Date

2027-01-01

Brief Summary

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Dietary protein intake is essential for tissue renewal and growth. Current recommendations for protein intake are based on studies using egg protein as reference protein. Egg protein is an animal-based protein with a high quality. Protein quality is determined by the composition of (essential) amino acids and digestibility. Therefore, different proteins have a different quality. Due to the environmental crisis, an increasing number of people consumes more plant-based proteins. These plant-based proteins often have a lower protein quality compared to animal-based proteins. Therefore, the aim of this study is to investigate whether optimal protein intake depend on protein quality. The optimal protein intake of an animal-based protein with a high quality (milk) will be compared to the optimal protein intake of a plant-based protein with a low quality (wheat).

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Detailed Description

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Conditions

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Protein Metabolism

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Double-blind, randomized, parallel study design

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Protein beverages with milk- or wheat composition will look similar.

Study Groups

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MILK

Drink containing amino acid composition of milk protein

Group Type ACTIVE_COMPARATOR

MILK

Intervention Type OTHER

Drink containing amino acids in the composition of milk protein

WHEAT

Drink containing amino acid composition of wheat protein

Group Type ACTIVE_COMPARATOR

WHEAT

Intervention Type OTHER

Drink containing amino acids in the composition of wheat protein

Interventions

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MILK

Drink containing amino acids in the composition of milk protein

Intervention Type OTHER

WHEAT

Drink containing amino acids in the composition of wheat protein

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Aged between 65-85 years
* BMI between 18.5-30 kg\*m\^-2
* Healthy, recreationally active (maximal one intensive exercise training per week)
* No physical limitations (i.e., able to perform all activities associated with daily living independently)

Exclusion Criteria

* Smoking
* Diagnosed musculoskeletal disorders
* Use of any medications known to affect protein metabolism (i.e., corticosteriods, non-steroidal anti-inflammatories)
* Chronic use of gastic acid-suppressing medication or anti-coagulants
* Unstable weight over the last 3 months
* Diagnosed GI tract disorders or diseases
* Blood donation in the past 2 months

Minimum Eligible Age

65 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes