Study of Attentional Disorders in Patients Suffering From Idiopathic Generalized Epilepsy.

NCT ID: NCT05530109

Last Updated: 2025-05-15

Basic Information

• Recruitment Status: TERMINATED
• Total Enrollment: 33 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2022-04-26
• Study Completion Date: 2025-04-25

Brief Summary

Attentional disorders have been reported in neuropsychological studies evaluating patients suffering from generalized idiopathic epilepsy, but the data are disparate (in terms of test protocol). We aim to describe attentional and executive function disorder in IGE thanks to the Epitrack scale, validated in this specific population. Our secondary objective is to study the dynamic of cortical activity during an attentional task (the ANT), in order to describe the alteration of cortical networks in epileptic patients presenting with attentional disturbance.

Conditions

Idiopathic Generalized Epilepsy

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: PROSPECTIVE

Study Groups

Patients with idiopathic generalised epilepsy

Neuropsychological screening and high resolution EEG recording

Intervention Type: OTHER

Each participant will be assessed with a battery of neuropsychological tests including Epitrack, the Raven's progressive matrice, the MoCA, the D2-R test, the BDI-II test, the STAI and the Qolie-31. Then, a prolonged EEG recording at rest and during an attentional task (the ANT) will be realized

healthy controls

age- and sex-matched healthy controls

Neuropsychological screening and high resolution EEG recording

Intervention Type: OTHER

Each participant will be assessed with a battery of neuropsychological tests including Epitrack, the Raven's progressive matrice, the MoCA, the D2-R test, the BDI-II test, the STAI and the Qolie-31. Then, a prolonged EEG recording at rest and during an attentional task (the ANT) will be realized

Interventions

Neuropsychological screening and high resolution EEG recording

Each participant will be assessed with a battery of neuropsychological tests including Epitrack, the Raven's progressive matrice, the MoCA, the D2-R test, the BDI-II test, the STAI and the Qolie-31. Then, a prolonged EEG recording at rest and during an attentional task (the ANT) will be realized

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Idiopathic generalized epilepsy followed-up during at least 2 years
• At least one antiepileptic drug medication
• No cognitive decline (MoCA score >26)
• Absence of concomitant pathology that could interfere with the purpose of the study.
• Be affiliated to the social security system
• Have signed an informed consent

Exclusion Criteria

• Pregnancy
• Not able to give consent (Article 1121-8 of the CSP) Vulnerable person Being deprived of liberty by judicial or administrative decision (Article L 1121-6 of the CSP) Have a high probability of not respecting the protocol or of abandoning the study

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University Hospital, Lille

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Philippe DERAMBURE, MD,PhD

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Lille

Locations

Hopital Roger Salengro, CHU Lille

Lille, , France

Countries

France

Other Identifiers

2022-A00263-40

Identifier Type: OTHER

Identifier Source: secondary_id

2021_0848

Identifier Type: -

Identifier Source: org_study_id