Subjective Perception of Motor Control During Psychogenic Disorders
NCT ID: NCT02843932
Last Updated: 2020-11-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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TERMINATED
NA
14 participants
INTERVENTIONAL
2015-05-13
2019-06-30
Brief Summary
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The Hospital University Center of Grenoble will provide patients from Neurology department, characterized with non psychogenic epileptic seizures and abnormal psychogenic movements, from conversive origin.
Subjects will be scanned by Magnetic Resonance Imaging during a motor paradigm inducing a perceptive conflict between two informations : proprioceptive information coming from the action (drawing) and visual information (draw's mark) that appears on the screen when there is movement.
Detailed Description
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Conditions
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Keywords
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Study Design
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NA
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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Psychogenic disorders
Psychogenic movement disorders and seizures
functional brain MRI
functional imagery during motor-perception tasks
Interventions
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functional brain MRI
functional imagery during motor-perception tasks
Eligibility Criteria
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Inclusion Criteria
* Medical exam médical done before study participation
* Between 18 and 65 years
* Right-handed persons
* Conversion disorder based on DSM IV-R criterias
* Symptom affecting motor system, like abnormal movements (shivers, dystonia, parkinsonism, or problem when walking)
Exclusion Criteria
* People with MRI contraindications : prosthesis or metal implants, metallic teeth (dental) brace, pacemaker, IUD, possibility of pregnancy, claustrophobia
* Traitement médicamenteux psychotrope ou susceptible d'interférer avec le débit sanguin cérébral ou l'activité neuronale
* History of brain or disseminated and extendible lesions of white matter, of an other degenerative morbidity, a confusion or an insanity as well as serious deficits preventing language understanding.
* Alcohol ingestion
* Pregnant, parturient or breastfeeding women
* All other categories of protected persons
18 Years
65 Years
ALL
No
Sponsors
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University Hospital, Grenoble
OTHER
Responsible Party
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Principal Investigators
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Tiphaine Montagnon
Role: STUDY_CHAIR
DRCI, CHU GRENOBLE, FRANCE
Locations
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Chu Grenoble
Grenoble, , France
Countries
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References
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Desmurget M, Grafton S. Forward modeling allows feedback control for fast reaching movements. Trends Cogn Sci. 2000 Nov 1;4(11):423-431. doi: 10.1016/s1364-6613(00)01537-0.
Wolpert DM, Ghahramani Z, Jordan MI. An internal model for sensorimotor integration. Science. 1995 Sep 29;269(5232):1880-2. doi: 10.1126/science.7569931.
Sabes PN. The planning and control of reaching movements. Curr Opin Neurobiol. 2000 Dec;10(6):740-6. doi: 10.1016/s0959-4388(00)00149-5.
Rothwell JC, Traub MM, Day BL, Obeso JA, Thomas PK, Marsden CD. Manual motor performance in a deafferented man. Brain. 1982 Sep;105 (Pt 3):515-42. doi: 10.1093/brain/105.3.515.
Ghez C, Hening W, Gordon J. Organization of voluntary movement. Curr Opin Neurobiol. 1991 Dec;1(4):664-71. doi: 10.1016/s0959-4388(05)80046-7.
van Beers RJ, Baraduc P, Wolpert DM. Role of uncertainty in sensorimotor control. Philos Trans R Soc Lond B Biol Sci. 2002 Aug 29;357(1424):1137-45. doi: 10.1098/rstb.2002.1101.
Fourneret P, Jeannerod M. Limited conscious monitoring of motor performance in normal subjects. Neuropsychologia. 1998 Nov;36(11):1133-40. doi: 10.1016/s0028-3932(98)00006-2.
Carson AJ, Stone J, Warlow C, Sharpe M. Patients whom neurologists find difficult to help. J Neurol Neurosurg Psychiatry. 2004 Dec;75(12):1776-8. doi: 10.1136/jnnp.2003.032169.
Vuilleumier P, Chicherio C, Assal F, Schwartz S, Slosman D, Landis T. Functional neuroanatomical correlates of hysterical sensorimotor loss. Brain. 2001 Jun;124(Pt 6):1077-90. doi: 10.1093/brain/124.6.1077.
Cojan Y, Waber L, Carruzzo A, Vuilleumier P. Motor inhibition in hysterical conversion paralysis. Neuroimage. 2009 Sep;47(3):1026-37. doi: 10.1016/j.neuroimage.2009.05.023. Epub 2009 May 18.
Cojan Y, Vuilleumier P. Functional brain imaging of psychogenic paralysis during conversion and hypnosis
Hallet M, cloninger CR, Fahn S, Halligan P, Jankovic J, Lang AE, Voon V Psychogenic movement disorders and other conversion disorders. Cambridge University Press 2011
de Lange FP, Roelofs K, Toni I. Motor imagery: a window into the mechanisms and alterations of the motor system. Cortex. 2008 May;44(5):494-506. doi: 10.1016/j.cortex.2007.09.002. Epub 2007 Dec 23.
Blakemore SJ, Wolpert DM, Frith CD. Abnormalities in the awareness of action. Trends Cogn Sci. 2002 Jun 1;6(6):237-242. doi: 10.1016/s1364-6613(02)01907-1.
de Lange FP, Roelofs K, Toni I. Increased self-monitoring during imagined movements in conversion paralysis. Neuropsychologia. 2007 May 15;45(9):2051-8. doi: 10.1016/j.neuropsychologia.2007.02.002. Epub 2007 Feb 11.
Friston KJ, Holmes AP, Worsley KJ. How many subjects constitute a study? Neuroimage. 1999 Jul;10(1):1-5. doi: 10.1006/nimg.1999.0439.
Stone J, Carson A, Sharpe M. Functional symptoms in neurology: management. J Neurol Neurosurg Psychiatry. 2005 Mar;76 Suppl 1(Suppl 1):i13-21. doi: 10.1136/jnnp.2004.061663. No abstract available.
Other Identifiers
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38RC14.120*
Identifier Type: -
Identifier Source: org_study_id