Functional Link Between Hippocampal and Vestibular Systems: a Pilot Study in Epilepsy Surgery
NCT ID: NCT01285921
Last Updated: 2017-11-07
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
22 participants
INTERVENTIONAL
2011-02-28
2017-10-31
Brief Summary
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Detailed Description
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Hypothesis:
The human hippocampal formation plays a crucial role in various aspects of memory processing. Work in rodents and some other species emphasized the role of the hippocampus in spatial learning and memory as well. A few human studies also point to a direct relation between hippocampal size, navigation and spatial memory. Patients with acquired chronic bilateral vestibular loss develop a significant selective atrophy of the hippocampus (Brandt et al, 2005) and activation of lateral semicircular canal by caloric stimulation induces activation of hippocampal formation in f-MRI (VITTE et al, 1996). But the investigators still do not know the effects on vestibular responses of the removal of the hippocampal formation to cure temporal lobe epilepsy. If the hippocampal formation directly influences the vestibular response, an asymmetry of the vestibular responses should be recorded postoperatively.
Principal criterion Research for an asymmetry of the vestibular responses (Caloric test, Vestibular Evoked Myogenic potentials: VEMp, Head Impulse Test: HIT, Eye Rotational Test: ERI)
Inclusion criteria
* patients suffering of intractable mesial temporal lobe epilepsy and candidate for surgery,
* without history of any cochlea-vestibular disorder
* older than 18 years,
* French residents,
* with medicare,
* after signed informed consent. Exclusion criteria
* History of cochlea-vestibular disorder
* Pregnancy
Population
* 22 patients suffering of intractable epilepsy and candidate for surgery (10 right side and 10 left side).
* Evaluation before and after surgery
Methodology Vestibular function will be quantified by daily practice vestibular tests
* Research of a spontaneous nystagmus with and without fixation (VIDEONYSTAGMOSCOPY) and segmentary deviations (Fukuda test)
* HIT (testing semicircular canal function at high frequency). Results: Gain in %
* VEMp (testing saccular function). Results: Amplitude in μV and latency in ms
* ERI (testing lateral semicircular function at middle frequency). Results: Nystagmus during and after the rotations in frequency and slow phase velocity (SPV) in °/s
* Caloric test (testing lateral semicircular function at low frequency). Results: Canal paresis in % and SPV in °/S
Results Vestibular function will be quantified with daily practice vestibular tests
* Quantification of the vestibular asymmetry
* Ipsi or contralateral to the side of the surgery?
* Depending on the hemispheric dominance?
Conditions
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Keywords
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Study Design
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NA
SINGLE_GROUP
DIAGNOSTIC
SINGLE
Study Groups
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hippocampal surgery
Vestibular test before and after hippocampal surgery
Principal criterion:
Research for an asymmetry of the vestibular responses (Caloric test, Vestibular Evoked Myogenic potentials: VEMp, Head Impulse Test: HIT, Eye Rotational Test: ERI). Investigator performs a blind vestibular test (single blind)
vestibular test before and after hippocampal surgery
* Research of a spontaneous nystagmus with and without fixation(VIDEONYSTAGMOSCOPY) and segmentary deviations (Fukuda test)
* HIT (testing semicircular canal function at high frequency).Results: Gain in %
* VEMp (testing saccular function). Results: Amplitude in μV and latency in ms
* ERI (testing lateral semicircular function at middle frequency). Results: Nystagmus during and after the rotations in frequency and slow phase velocity (SPV) in °/s
* Caloric test (testing lateral semicircular function at low frequency). Results: Canal paresis in % and SPV in °/S
Interventions
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vestibular test before and after hippocampal surgery
* Research of a spontaneous nystagmus with and without fixation(VIDEONYSTAGMOSCOPY) and segmentary deviations (Fukuda test)
* HIT (testing semicircular canal function at high frequency).Results: Gain in %
* VEMp (testing saccular function). Results: Amplitude in μV and latency in ms
* ERI (testing lateral semicircular function at middle frequency). Results: Nystagmus during and after the rotations in frequency and slow phase velocity (SPV) in °/s
* Caloric test (testing lateral semicircular function at low frequency). Results: Canal paresis in % and SPV in °/S
Eligibility Criteria
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Inclusion Criteria
* without history of any cochlea-vestibular disorder
* older than 18 years,
* French residents,
* with medicare,
* after signed informed consent
Exclusion Criteria
* Pregnancy
18 Years
ALL
No
Sponsors
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Assistance Publique - Hôpitaux de Paris
OTHER
Responsible Party
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Principal Investigators
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Elizabeth Vitte, MD, PhD
Role: STUDY_DIRECTOR
Assistance Publique - Hôpitaux de Paris
Locations
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Hôpital BEAUJON
Clichy, , France
Countries
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Other Identifiers
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2010-A01220-39
Identifier Type: OTHER
Identifier Source: secondary_id
P100106
Identifier Type: -
Identifier Source: org_study_id