Changes in Attentional Control After a Focal Seizure.

NCT ID: NCT06466681

Last Updated: 2025-05-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-03-04

Study Completion Date

2027-03-09

Brief Summary

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Epilepsy is frequently associated with cognitive and attentional disorders. Several studies have pointed out that there are modifications of brain activity in resting state during peri-ictal period in EEG and functional MRI. However, to date, no study has assessed the changes in attentional control after a seizure. The investigators hypothesize that a localized discharge is associated with a disorganization of the networks engaged in attentional control. In this regard, the investigators propose a prospective longitudinal study assessing the changes in attentional control after a focal seizure.

Detailed Description

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Conditions

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Temporal Lobe Epilepsy Frontal Lobe Epilepsy Others Subtypes

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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All included subjects

Administration of the subtest of divided attention of the Test of Attentional Performance (TAP), recording of the event related potentiels N200 and P300, measure of the variation of power in several frequency bands (theta, alpha and beta) and measure of the high-resolution EEG connectivity during an attentional task at several time-points : a first time during interictal period (no seizure for more than 24 hours) and 1, 3, 6 and 24 hours after a focal seizure.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Age superior to 18 and under 80
* Focal epilepsy with indication to pre-surgery work-up and 5 days programmed hospitalization dedicated to this work-up
* Normal global cognitive performance (standard progressive Raven matrices score \> 5th percentile)
* Be affiliated to the social security system
* Have signed an informed consent

Exclusion Criteria

* Pregnancy or breastfeeding
* Not able to give consent (Article 1121-8 of the CSP)
* Vulnerable person
* Being deprived of liberty by judicial or administrative decision (Article L 1121-6 of the CSP)
* Guardianship
* Have a high probability of not respecting the protocol or of abandoning the study
* Absence of any epileptic seizure recorded during the hospitalization
* Recurrent seizures preventing the recording of at least 24 hours without any seizure following a seizure.
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Lille

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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University Hospital,

Lille, , France

Site Status RECRUITING

Countries

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France

Facility Contacts

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Philippe DERAMBURE, Pr

Role: primary

03 20 44 59 69

Other Identifiers

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2022_0762

Identifier Type: -

Identifier Source: org_study_id

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