Brain Excitability and Connectivity in Sensory-motor Pathways in ALS
NCT ID: NCT03694132
Last Updated: 2025-11-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
52 participants
INTERVENTIONAL
2018-11-26
2021-03-31
Brief Summary
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The secondary objective is to evaluate whether the observed functional changes in MEG / EEG and functional MRI correlate with structural lesions revealed with diffusion MRI (anatomo-functional connectivity of the brain).
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Detailed Description
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Functional MRI will be performed during electrical stimulation of ulnar nerve and during mechanical vibration of ADM tendon.
Brain diffusion MRI will be performed. Anatomical MRI will be done for source location. Brain resting state activity will be recorded with MEG/EEG and fMRI.
Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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functional MRI
a group of patients with ALS and a group of gender and age matched healthy subjects will have functional MRI acquisition conditioned by electrical and mechanical stimuli of ADM proprioceptors
functional MRI
conditioning brain activity with peripheral stimulations
structural MRI
a group of patients with ALS and a group of gender and age matched healthy subjects will have diffusion MRI acquisition to evaluate their brain structures
structural MRI
diffusion MRI and tractography for evaluating the brain structures
EEG/MEG
a group of patients with ALS and a group of gender and age matched healthy subjects will have functional MRI acquisition conditioned by electrical stimuli of ADM proprioceptors
EEG/MEG
conditioning brain activity with peripheral stimulations
Interventions
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functional MRI
conditioning brain activity with peripheral stimulations
structural MRI
diffusion MRI and tractography for evaluating the brain structures
EEG/MEG
conditioning brain activity with peripheral stimulations
Eligibility Criteria
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Inclusion Criteria
* Controls: no history of neurological disorders, right-handed
Exclusion Criteria
30 Years
80 Years
ALL
Yes
Sponsors
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Institut National de la Santé Et de la Recherche Médicale, France
OTHER_GOV
Responsible Party
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Principal Investigators
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Pierre-Francois Pradat, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Assistance Publique - Hôpitaux de Paris
Veronique Marchand-Pauvert, PhD
Role: STUDY_DIRECTOR
Institut National de la Santé Et de la Recherche Médicale, France
Locations
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Hopital Pitie-Salpetriere
Paris, , France
Countries
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References
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Sangari S, Giron A, Marrelec G, Pradat PF, Marchand-Pauvert V. Abnormal cortical brain integration of somatosensory afferents in ALS. Clin Neurophysiol. 2018 Apr;129(4):874-884. doi: 10.1016/j.clinph.2017.12.008. Epub 2017 Dec 24.
Benetton C, Preuilh A, Khamaysa M, Chaumon M, Lackmy-Vallee A, Er A, Pelegrini-Issac M, Querin G, Rouaux C, Pradat PF, Marchand-Pauvert V. Encephalography cross-frequency coupling and brain alteration in amyotrophic lateral sclerosis. Brain Commun. 2025 Jun 6;7(3):fcaf192. doi: 10.1093/braincomms/fcaf192. eCollection 2025.
Related Links
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This paper reports results
Other Identifiers
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C17-70
Identifier Type: -
Identifier Source: org_study_id
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