Factors Influencing of Pulse Pressure Variation (PPV)

NCT ID: NCT04802668

Last Updated: 2023-01-10

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 189 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2021-03-20
• Study Completion Date: 2022-07-30

Brief Summary

The investigators studied the predictive value of PPV in the patients with different influencing factors;and the method to improve the predictive value,which can improve the application of PPV in ICU.

Detailed Description

PPV can be used to predict fluid responsiveness in patients with circulatory shock.However, it is affected by many factors, which leads to the decrease of the applicability of PPV in ICU.Therefore, the investigators studied the predictive value of PPV in the patients with different influencing factors;and the method to improve the predictive value,which can improve the application of PPV in ICU.

Conditions

Haemodynamics; Fluid Responsiveness; Pulse Pressure Variation

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Circulatory failure patients

Circulatory failure patients requiring fluid responsiveness evaluation

Patients were ventilated with assist-control ventilation（A/C） mode at different tidal volume

Intervention Type: DEVICE

Ventilation mode was set to assist-control volume ventilation with different tidal volume, respiratory frequency 15 times/min, PEEP 5 centimeter water column.

spontaneous breathing and no spontaneous breathing

Intervention Type: BEHAVIORAL

Data were recorded when patients had and did not have spontaneous breathing

Interventions

Patients were ventilated with assist-control ventilation（A/C） mode at different tidal volume

Ventilation mode was set to assist-control volume ventilation with different tidal volume, respiratory frequency 15 times/min, PEEP 5 centimeter water column.

Intervention Type: DEVICE

spontaneous breathing and no spontaneous breathing

Data were recorded when patients had and did not have spontaneous breathing

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• Patients requiring invasive mechanical ventilation
• Acute circulatory failure,defined as:systolic blood pressure <90 mmHg or blood pressure in patients with previous hypertension lower than the baseline value> 40 mmHg; vasoactive drugs are required to maintain blood pressure (mean arterial pressure> 65 mmHg); with or without signs of hypoperfusion (oliguria<0.5ml.kg-1.h-1 for at least 2 hours; arterial blood lactic acid>2.5mmol.L-1; skin mottling)

Exclusion Criteria

• The age of the patient is less than 18 years old or more than 80 years old
• Refuse to sign the informed consent to join the group
• Atrial fibrillation and other arrhythmias that seriously affect the output per beat;
• With pregnancy
• Other situations where the clinician believes that the patient is not suitable for inclusion in the study

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Southeast University, China

OTHER

Sponsor Role: lead

Responsible Party

Ling Liu

Clinical Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Haibo Qiu, MD

Role: STUDY_DIRECTOR

professor

Locations

Ling Liu

Nanjing, Jiangsu, China

Countries

China

References

Chen H, Liang M, He Y, Teboul JL, Sun Q, Xie J, Yang Y, Qiu H, Liu L. Inspiratory effort impacts the accuracy of pulse pressure variations for fluid responsiveness prediction in mechanically ventilated patients with spontaneous breathing activity: a prospective cohort study. Ann Intensive Care. 2023 Aug 17;13(1):72. doi: 10.1186/s13613-023-01167-0.

Reference Type: DERIVED

PMID: 37592166 (View on PubMed)

Other Identifiers

20210101PPV

Identifier Type: -

Identifier Source: org_study_id