Effects of Chest Wall Elastance on Pulmonary Mechanics of Acute Respiratory Failure (ARF)

NCT ID: NCT02196870

Last Updated: 2015-06-24

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 12 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2014-07-31
• Study Completion Date: 2015-06-30

Brief Summary

Patients with chest wall elastance increasing could worsen lung function. Increasing of chest wall elastance plays a great role in lung mechanics, and could influence mechanical ventilation settings. Therefore, It could help the physicians to find appropriate indicators and optimize the treatments of ARF patients to explore the mechanisms of lung mechanics changse in the patients with high chest wall elastance.

Detailed Description

Mechanical ventilation(MV) is an important treatment for acute respiratory failure(ARF) patients, could improve hypoxemia, maintain lung volume and promote alveolar opening. However, because of barotrauma, volutrauma and biotrauma, MV could cause or aggravate acute lung injury not only in acute respiratory distress syndrome(ARDS) patients, but in patients with normal lung function1,2.

Patients with chest wall elastance increasing could worsen lung function. Increasing of chest wall elastance plays a great role in lung mechanics, and could influence mechanical ventilation settings. Therefore, It could help the physicians to find appropriate indicators and optimize the treatments of ARF patients to explore the mechanisms of lung mechanics changse in the patients with high chest wall elastance.

The present study is set out to examine the effects of high chest wall elastance on changes of lung mechanics and the correlation of airway pressure(Paw) stress index and transpulmonary pressure(PL) stress index.

Conditions

Airway Pressure Stress Index; Transpulmonary Pressure Stress Index; Acute Respiratory Failure; Chest Wall Elastance

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• ARF
• mechanical ventilation
• cardiovascular stable

Exclusion Criteria

• age < 18y or > 85y
• pregnancy
• COPD or chronic pulmonary disease

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 85 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Southeast University, China

OTHER

Sponsor Role: lead

Responsible Party

Jianfeng Xie

Department of Critical Care Medicine, Zhong-Da Hospital

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Jianfeng Xie, Dr.

Role: PRINCIPAL_INVESTIGATOR

Zhongda hospital, Southeast University, Jiangsu, China

Locations

Zhongda Hospital

Nanjing, Jiangsu, China

Countries

China

References

Pan C, Chen L, Zhang YH, Liu W, Urbino R, Ranieri VM, Qiu HB, Yang Y. Physiological Correlation of Airway Pressure and Transpulmonary Pressure Stress Index on Respiratory Mechanics in Acute Respiratory Failure. Chin Med J (Engl). 2016 Jul 20;129(14):1652-7. doi: 10.4103/0366-6999.185855.

Reference Type: DERIVED

PMID: 27411451 (View on PubMed)

Other Identifiers

Chest wall Elastance in ARF

Identifier Type: -

Identifier Source: org_study_id