The Effects of Different Ventilation Modes on Patients With Pulmonary Lobe Resection

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

102 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-01-01

Study Completion Date

2025-05-31

Brief Summary

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The objective of this study was to discuss the effects of different ventilation modes on patients with plasma inflammatory factor and respiratory function in patients with pulmonary removal.

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Detailed Description

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Patients who meet the inclusion criteria will be numbered in the order of admission, and a dedicated person will prepare codes and opaque envelopes for random allocation. This study was divided into 3 groups, one groups was ventilation side volume control ventilation+continuous positive pressure ventilation on the non ventilation side, the other groups was ventilation side volume control ventilation+continuous positive pressure ventilation on the non ventilation side; the other groups was ventilation side pressure regulated volume control ventilation+continuous positive pressure ventilation on the non ventilation side.

Conditions

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Lung Injury Lung Inflammation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SEQUENTIAL

This study was divided into 3 groups, one groups was ventilation side volume control ventilation+continuous positive pressure ventilation on the non ventilation side, the other groups was ventilation side volume control ventilation+continuous positive pressure ventilation on the non ventilation side; the other groups was ventilation side pressure regulated volume control ventilation+continuous positive pressure ventilation on the non ventilation side.

Primary Study Purpose

OTHER

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

The researchers in this study enrolled suitable patients using a random number table method before surgery, and then performed different intraoperative single lung ventilation modes according to the grouping after unblinding the patients upon entering the room. The postoperative follow-up personnel or data analysts are unaware of the grouping status.

Study Groups

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Group VCV+CPAP

Ventilation side volume control ventilation+continuous positive pressure ventilation on the non ventilation side

Group Type EXPERIMENTAL

Adopting different ventilation modes during the operation

Intervention Type PROCEDURE

The ventilation side adopts different ventilation modes combined with continuous positive pressure ventilation on the surgical side.

Group PCV+CPAP

Ventilation side pressure control ventilation+continuous positive pressure ventilation on the non ventilation side

Group Type EXPERIMENTAL

Adopting different ventilation modes during the operation

Intervention Type PROCEDURE

The ventilation side adopts different ventilation modes combined with continuous positive pressure ventilation on the surgical side.

Group PRVC+CPAP

Ventilation side pressure regulated volume control ventilation+continuous positive pressure ventilation on the non ventilation side

Group Type EXPERIMENTAL

Adopting different ventilation modes during the operation

Intervention Type PROCEDURE

The ventilation side adopts different ventilation modes combined with continuous positive pressure ventilation on the surgical side.

Interventions

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Adopting different ventilation modes during the operation

The ventilation side adopts different ventilation modes combined with continuous positive pressure ventilation on the surgical side.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

Comprehensive examination and analysis of imaging, laboratory examination and other comprehensive examinations, the diagnosis is clear, which is in line with lobe resection surgical indications

Age 18-75 years old, the gender is not limited;

ASA grading Ⅰ \~ III level;

It is expected that the single lung ventilation time is ≥1 hours, and ≤3 hours

Exclusion Criteria

Emergency surgery;

There is a taboos on the existence of systemic anesthesia;

There is a history of acute chronic upper respiratory infections in the past January;

Previous bronchial asthma, chronic obstructive pulmonary disease, bronchial dilatation, phthisis ,aspergillosis , acute respiratory distress syndrome or history of respiratory failure;

Merge the function of important organs such as heart, liver, and kidney;

There was a history of chest surgery and the history of trauma;

Preoperative lung function test obvious abnormal abnormal abnormalities (1 second of exhalation (FEV1) \<60%);

Patients refuse to participate in the clinical trial

Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No