Effect of Mechanical Ventilation on Lung Development of Alveolar Stage

NCT ID: NCT05498922

Last Updated: 2022-08-12

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 100 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2021-04-27
• Study Completion Date: 2022-05-31

Brief Summary

Human lung development begins at about 4-7 post-conception weeks (pcw), and lasts until 3 years after birth, which can be divided into five morphological stages. Alveolar stage is the last stage during which alveoli forms, contributing to the rapid increase of gas exchange surface. Alveolar stage spans from 36 pcw to age 3, so it could be influenced by external factors. Mechanical ventilation (MV) is not only an important rescue method for children with respiratory distress, but also an indispensable respiratory support for young children during surgeries. When ventilators expand alveoli by pushing gas into lung with positive pressure, it acts against physiological characteristics and was reported to cause ventilator-induced lung injury. However, for children under the age of 3 with healthy lung, whether and how MV affects lung development has not been clearly elucidated.

Pressure-controlled ventilation is the most common utilized ventilating method in neonates and infants, which adjusts peak inspiratory pressure (PIP) as needed to meet oxygenation and ventilation goal. Under same PIP, will tidal volume (Vt), mean airway pressure (MAP) be variable based largely on the patients' respiratory mechanics like lung compliance and airway resistance. Therefore, how previous MV affects the alveolar stage of lung development can be partly indicated by analyzing and comparing indices like Vt, MAP and lung compliance when collected under same ventilator settings in later MV.

Approved by the Ethics Committee of Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, and written informed consents obtained from all patients' guardians, this clinical research collected data from retinoblastoma patients under the age of 3, when undergoing transcatheter intracranial vascular embolization (TIVE), one of the main Rb treatments. These data can be divided into 3 categories,

• Patient characteristics, including age in days, gender, height and weight;
• Surgery information, including total number of operation and date of each operation;
• Mechanical ventilation information, including ventilation duration, Vt, lung compliance, MAP and PIP.

The respective contribution of PIP, operation number, age and body mass index (BMI) to Vt per BMI, pulmonary compliance and MAP were quantified as estimate with their significance (showed as p value), which were obtained by regression analysis.

More details are described in Detailed Description as follow.

Detailed Description

Human lung development begins in the early stage of intrauterine pregnancy, approximately 4-7 post-conception weeks (pcw), and lasts until 3 years after birth. It can be divided into five morphological stages, namely embryonic stage, pseudoglandular stage, canalicular stage, saccular stage and alveolar stage. Alveolar stage is the process of alveolar formation during which distal saccules subdivide into alveoli and fuse into capillary until completely surround it, contributing to the rapid increase of gas exchange surface. Alveolar stage spans from 36 pcw to 3 years of age, and thus could be influenced by external factors.

Mechanical ventilation (MV) is not only an important rescue method for critically ill children with respiratory distress, but also an indispensable respiratory support method for young children during pediatric surgeries. Different from spontaneous breathing which creates negative pressure in chest to bring in air, ventilators expand alveoli by pushing gas into lung with positive pressure. Therefore, no matter how ventilator nowadays has been optimized to provide breathing movement close to the natural breathing, it still acts against physiological characteristics and has been reported to cause ventilator-induced lung injury when giving respiratory support to both pediatric and adult patients in intensive care unit. However, for children under the age of 3 with healthy pulmonary system, whether and how MV affects the alveolar stage of lung development has not been clearly elucidated.

Pressure-controlled ventilation is the most common utilized ventilating method in neonates and infants, which adjusts peak inspiratory pressure (PIP) as needed to meet oxygenation and ventilation goal. Under same PIP, will tidal volume (Vt), mean airway pressure (MAP) be variable based largely on the patients' respiratory mechanics like lung compliance and airway resistance. Therefore, how previous MV affects the alveolar stage of lung development can be partly indicated by analyzing and comparing indices like Vt, MAP and lung compliance when collected under same ventilator settings in later MV.

Retinoblastoma (Rb) is a rare form of cancer that rapidly develops from the immature cells of a retina, the light-detecting tissue of the eye. It is the most common malignant cancer of the eye in children, and it is almost exclusively found in young children. Transcatheter intracranial vascular embolization (TIVE) is one of the main treatments for Rb, and to assure the smooth operation in pediatric children for their poor medical compliance, general anesthesia and MV are compulsory during TIVE. Given TIVE is usually performed time and time again to help attenuating cancer growth and delaying the diseased eye removal, we can infer the influence of MV on infant lung development by analyzing the contribution of MV operation number, which is also the TIVE operation times, to respiratory indices, with the premise that TIVE operation duration is nearly equal when it is operated by same clinical group.

Approved by the Ethics Committee of Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, and written informed consents obtained from all patients' guardians, this clinical research collected data from Rb patients under the age of 3, when undergoing TIVE. These data can be divided into 3 categories,

• Patient characteristics, including age in days, gender, height and weight;
• Surgery information, including total number of operation and date of each operation;
• Mechanical ventilation information, including ventilation duration, Vt, lung compliance, MAP and PIP under setting parameters recommended by the guidance of mechanical ventilation in neonates and children (https://doi.org/10.1007/978-3-030-83738-9_8).

The respective contribution of PIP, operation number, age and body mass index (BMI) to Vt per BMI, pulmonary compliance and MAP will be quantified as estimate with their significance (showed as p value), which can be obtained by regression analysis through statistical software SPSS Statistics. P < 0.05 is considered as statistically significant criteria.

Conditions

Mechanical Ventilation; Abnormal Lung Development

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: PROSPECTIVE

Interventions

Peak pressure when mechanical ventilation was switched around a reasonable range

The research protocol was approved by the Ethics Committee of Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, and written informed consents were obtained from all patients. After induction of anesthesia, Rb patients were transorally intubated and mechanically ventilated. The inspiratory time, ventilation rate, positive end-expiratory pressure, and oxygen concentration were set consistently among patients. When anesthesiologist switch the peak pressure around a reasonable range, indices including tidal volume, lung compliance, mean airway pressure on ventilator screen changed and were recorded when stable. All the ventilator setting parameters followed the guidance of mechanical ventilation in neonates and children (https://doi.org/10.1007/978-3-030-83738-9\_8). All the anesthesia and ventilation performance were conducted by a fully qualified senior anesthesiologist to assure standardized and safe anesthesia, ventilation and operation procedure.

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

• Age 0~3;
• History of full-term birth;
• Normal physical development in height and weight;
• Supine position during operation;

Exclusion Criteria

• Congenital pulmonary dysplasia;
• Current or previous lung disease;
• Chest deformity;
• Additional interference to pulmonary breathing except MV during data collection;
• being involved in other clinical subjects.

• Maximum Eligible Age: 3 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Xinhua Hospital, Shanghai Jiao Tong University School of Medicine

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Lai Wang, Chief doctor

Role: PRINCIPAL_INVESTIGATOR

Department of Anesthesia, Shanghai Xinhua hospita

Locations

Department of Anesthesia, Shanghai Xinhua hospital

Shanghai, Shanghai Municipality, China

Countries

China

References

Fernandes N., Chawla S. (2022) Mechanical Ventilation for Neonates. In: Sarnaik A.P., Venkataraman S.T., Kuch B.A. （eds） Mechanical Ventilation in Neonates and Children. Springer, Cham. https://doi.org/10.1007/978-3-030-83738-9_8

Reference Type: BACKGROUND

Provided Documents

Document Type: Study Protocol

View Document

Document Type: Informed Consent Form

View Document

Related Links

http://doi.org/10.1007/978-3-030-83738-9_8

guidance of mechanical ventilation in neonates and children

Other Identifiers

XH-21-12

Identifier Type: -

Identifier Source: org_study_id