Ventilator Mode and Respiratory Physiology

NCT ID: NCT06624254

Last Updated: 2024-10-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ENROLLING_BY_INVITATION

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-09-21

Study Completion Date

2029-09-30

Brief Summary

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Modern intensive care units (ICUs) are increasingly adopting newer modes of mechanical ventilation such as adaptive pressure control (APC) modes but there are limited data available regarding risks and benefits of newer modes versus traditional ventilation modes. APC can inadvertently deliver high tidal volumes, which maybe harmful. High tidal volumes may be unrecognized by the provider, due to the complexities of ventilator algorithms and patient interactions. The objective of this aim is to identify risk factors for excess tidal volumes in patients on adaptive pressure control.

Detailed Description

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Conditions

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Pulmonary Disease Respiratory Failure Respiratory Effort Breathing Mechanics

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Adaptive Pressure Control

On adaptive pressure control mode with acute respiratory failure

lung mechanics, respiratory drive and effort

Intervention Type OTHER

Patient lung mechanics and respiratory drive and effort will be measured

Interventions

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lung mechanics, respiratory drive and effort

Patient lung mechanics and respiratory drive and effort will be measured

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Admitted to ICU with acute respiratory failure
* On adaptive pressure control mode of ventilation
* Tidal volumes set between 5-8 cc/kg ideal body weight

Exclusion Criteria

* Current use of neuromuscular blockade
* Inability to obtain consent from patient or surrogate decision maker
* Treating clinician refusal
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of California, San Diego

OTHER

Sponsor Role lead

Responsible Party

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Alex Pearce

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Alex Pearce, MD

Role: PRINCIPAL_INVESTIGATOR

University of California, San Diego

Locations

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University of California San Diego Health

La Jolla, California, United States

Site Status

Countries

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United States

Other Identifiers

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807319

Identifier Type: -

Identifier Source: org_study_id

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