The Use of Constant-flow Technique for Determining the Lower Inflexion Point of Pressure-volume Curve and Intrinsic PEEP During One-lung Ventilation
NCT ID: NCT01532245
Last Updated: 2018-10-25
Study Results
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Basic Information
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WITHDRAWN
NA
INTERVENTIONAL
2011-12-31
2018-10-23
Brief Summary
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Methods: After IRB approval and written, informed consent, data were obtained from 20 patients during OLV for thoracic surgery who were ventilated with an AVEA (VIASYS Healthcare) critical-care ventilator. During two-lung ventilation (TLV) and OLV 8 ml•kg-1 tidal volume was used. During OLV, ventilation periods of ten minutes, with and without 5 cmH2O PEEP were alternated. During each period, the investigators recorded arterial blood partial pressures, respiratory and hemodynamic values, intrinsic PEEP (PEEPi), and LIP. PEEPi and LIP were determined using the automatic mode of the ventilator; specifically, LIP was determined with a continuous flow of 3L/minute.
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
SINGLE_GROUP
OTHER
NONE
Study Groups
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two-lung ventilation (TLV)
During two-lung ventilation (TLV) and OLV 8 ml•kg-1 tidal volume was used.
two lung ventilation (TLV)
During two-lung ventilation (TLV) and OLV 8 ml•kg-1 tidal volume was used.
one lung ventillation (OLV) without PEEP
During OLV, ventilation periods of ten minutes, with and without 5 cmH2O positive end-expiratory pressure (PEEP) were alternated.
one lung ventilation (OLV) without PEEP
During OLV, ventilation periods of ten minutes, with and without 5 cmH2O positive end-expiratory pressure (PEEP) were alternated.
one lung ventilation (OLV) with PEEP
During OLV, ventilation periods of ten minutes, with and without 5 cmH2Opositive end-expiratory pressure (PEEP) were alternated
One lung ventilation (OLV) with positive end-expiratory pressure (PEEP)
During OLV, ventilation periods of ten minutes, with and without 5 cmH2O positive end-expiratory pressure (PEEP) were alternated
Interventions
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two lung ventilation (TLV)
During two-lung ventilation (TLV) and OLV 8 ml•kg-1 tidal volume was used.
one lung ventilation (OLV) without PEEP
During OLV, ventilation periods of ten minutes, with and without 5 cmH2O positive end-expiratory pressure (PEEP) were alternated.
One lung ventilation (OLV) with positive end-expiratory pressure (PEEP)
During OLV, ventilation periods of ten minutes, with and without 5 cmH2O positive end-expiratory pressure (PEEP) were alternated
Eligibility Criteria
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Inclusion Criteria
18 Years
ALL
No
Sponsors
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The Cleveland Clinic
OTHER
Responsible Party
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Principal Investigators
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Tamás Végh,, M.D.
Role: PRINCIPAL_INVESTIGATOR
Klinikum Ludwigshafen
Other Identifiers
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DEOEC RKEB/IKEB 3504-2011
Identifier Type: -
Identifier Source: org_study_id
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