Exercise-stimulated Muscle Glucose Uptake in Upper Body Obesity

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

48 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-11-06

Study Completion Date

2026-07-31

Brief Summary

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The purpose of this study is to provide the first integrated examination of the interaction between muscle insulin action and exercise-stimulated muscle glucose uptake in obesity from the whole body to the cellular/molecular level.

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Detailed Description

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Conditions

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Upper Body Obesity

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

This study is aimed to determine whether obesity effects muscle glucose utilization during exercise.

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Lean

Control

Group Type OTHER

Exercise

Intervention Type OTHER

Cycling 60% VO2 max

Obese

Group Type EXPERIMENTAL

Exercise

Intervention Type OTHER

Cycling 60% VO2 max

Interventions

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Exercise

Cycling 60% VO2 max

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

For the exercise studies of leg glucose uptake - "insulin sensitive" group:

* Sedentary, normal weight, premenopausal women.
* Sedentary, age-matched normal weight men.
* Weight stable for two (2) months prior to study.
* Willing to provide written, informed consent.
* For the exercise studies of leg glucose uptake - "insulin resistant" group:

For the exercise studies of leg glucose uptake - "insulin resistant" group:

* Upper body obese (UBO) premenopausal women.
* Age-matched upper body obese (UBO) men.
* Weight stable for two (2) months prior to study.
* Willing to provide written, informed consent.

Exclusion Criteria

* Age \< 18 or \> 55 years (premenopausal women and age-matched men).
* Use of glucose-lowering agents.
* For female subjects: positive pregnancy test at the time of enrollment or study
* History of prior upper abdominal surgery such as adjustable gastric banding, pyloroplasty and vagotomy.
* Active systemic illness or malignancy.
* Symptomatic macrovascular or microvascular disease.

Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes