Body Weight and Carb Metabolism

NCT ID: NCT05330481

Last Updated: 2024-09-19

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 20 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2022-03-01
• Study Completion Date: 2024-07-27

Brief Summary

Whilst theoretically, body size should influence the capacity for intestinal carbohydrate absorption and thus exogenous oxidation rates during exercise, there is currently little empirical evidence to support this hypothesis. Accordingly, current nutrition guidelines for carbohydrate intake during exercise do not take body mass into account. Therefore, there is a need to establish whether body mass is related to exogenous carbohydrate oxidation rates during exercise. If such a relationship is established, this would lay the foundation to revise the current sports nutrition guidelines regarding carbohydrate intake during exercise.

The aims of this study are, therefore, to: 1) establish whether larger individuals display higher rates of exogenous carbohydrate oxidation than smaller individuals; and 2) establish if such a difference can be explained by the higher absolute exercise intensity, and thus the energy demand of exercise. It is hypothesised that larger individuals will demonstrate higher exogenous carbohydrate oxidation rates than smaller individuals, and that this difference will be partly (but not completely) diminished when the absolute intensity of exercise is matched.

Conditions

Exercise Metabolism

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

<70 kg body mass

Cyclists or triathletes with a body mass of less than 70 kg

Moderate-intensity (relative) exercise with glucose ingestion

Intervention Type: OTHER

120 minutes of cycling at 95% of lactate threshold ingesting 90 g/h of glucose

>70 kg body mass

Cyclists or triathletes with a body mass of less than 70 kg

Moderate-intensity (relative) exercise with glucose ingestion

Intervention Type: OTHER

120 minutes of cycling at 95% of lactate threshold ingesting 90 g/h of glucose

Moderate-intensity (absolute) exercise with glucose ingestion

Intervention Type: OTHER

120 minutes of cycling at a power matched to participant in the \<70 kg body mass group, ingesting 90 g/h of glucose

Interventions

Moderate-intensity (relative) exercise with glucose ingestion

120 minutes of cycling at 95% of lactate threshold ingesting 90 g/h of glucose

Intervention Type: OTHER

Moderate-intensity (absolute) exercise with glucose ingestion

120 minutes of cycling at a power matched to participant in the \<70 kg body mass group, ingesting 90 g/h of glucose

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Able to cycle continuously for 2 hours at a moderate intensity
• VO2max of between 40-75 mL/kg/min
• Fat-mass index (determined by dual energy x-ray absorptiometry) < 5.5 kg·m-2

Exclusion Criteria

• Diagnosed disorders of the gastrointestinal tract (e.g. crohn's, colitis etc.)
• People following a low-carbohydrate, high-fat diet
• Pregnant or lactating
• Diagnosed cardiovascular disease
• Possible symptoms of cardiovascular disease
• Diagnosis of diabetes of any type
• Hypercholesterolaemia (total cholesterol ≥ 6.2 mmol/L
• Hypertension (systolic blood pressure ≥140 mmHg or diastolic blood pressure ≥90 mmHg)
• Current smoker
• Family history of coronary artery disease (first-degree relative <60 years)
• Prevalence of vascular disease
• Autonomic neuropathy
• Kidney disease
• Diagnosed pulmonary disease (e.g. chronic obstructive pulmonary disease, asthma, interstitial lung disease or cystic fibrosis)
• Blood borne disease or infection
• Osteoporosis
• Osteoarthritis
• Blood clotting disorders
• Food intolerances/allergies (these may not specifically exclude you- please talk to the investigator)
• Sensitivity or allergy to anaesthetic

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University of Birmingham

OTHER

Sponsor Role: collaborator

University of Bath

OTHER

Sponsor Role: lead

Responsible Party

Javier Gonzalez

Reader (Associate Professor) in Human Physiology

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Department for Health, University of Bath

Bath, , United Kingdom

Countries

United Kingdom

Other Identifiers

6632

Identifier Type: -

Identifier Source: org_study_id