Fat Metabolism in Response to Acute Diet- and Exercise-induced Changes in Energy Balance
NCT ID: NCT00830999
Last Updated: 2013-01-21
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
12 participants
INTERVENTIONAL
2006-04-30
2012-12-31
Brief Summary
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Detailed Description
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Weight loss and endurance exercise improve plasma lipid and lipoprotein concentrations. However, the mechanisms responsible for this effect are largely unknown, and much uncertainty remains regarding the independent roles of dietary energy intake, exercise energy expenditure, and net energy balance in controlling plasma TG concentrations.
The main goal of this project, therefore, is to investigate the mechanisms by which acute alterations in energy balance, induced by diet and/or physical activity (endurance exercise), regulate very-low density lipoprotein (VLDL) metabolism.
Subjects will be asked to perform 3 separate trials. One of these will always be an "energy balance" trial that will act as the control trial for the other 2 trials they perform. Subjects will therefore be randomized to 2 different study arms.
Conditions
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Study Design
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RANDOMIZED
SINGLE_GROUP
PREVENTION
NONE
Study Groups
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Positive energy balance
Comparison between isocaloric and hypercaloric diets with no exercise performed in any trials
Positive energy balance
Subjects will consume over a 24 hour period 33% more calories than they require to meet their energy demands.
Energy balance
Subjects will consume over a 24 hour period a sufficient amount of calories to meet their energy needs.
Energy balance with exercise
Comparison between an isocaloric diet without exercise and a hypercaloric diet with a sufficient amount of exercise performed to match the excess calories consumed resulting in both trials being in net energy balance.
Energy balance with exercise
Subjects will consume over a 24 hour period 33% more calories than they require to meet their energy demands but will perform 2 hours of exercise that will be sufficient to burn off the excess calories consumed resulting in subjects being in net energy balance.
Energy balance
Subjects will consume over a 24 hour period a sufficient amount of calories to meet their energy needs.
Negative energy balance
Comparison between isocaloric and hypocaloric diets with no exercise performed in any trials
Negative energy balance
Subjects will consume over a 24 h period only 66% of the calories required to meet their energy demands such that they will be in a net negative calorie balance in this trial.
Energy balance
Subjects will consume over a 24 hour period a sufficient amount of calories to meet their energy needs.
Negative energy balance with exercise
Comparison between consuming an isocaloric diet without exercise and consuming the same amount of calories as in the isocaloric trial but with exercise performed resulting in net negative energy balance in the exercise trial.
Negative energy balance with exercise
Subjects will consume over a 24 hour period the same amount of calories as ingested in the isocaloric trial but will also perform 2 hours of exercise that will be sufficient to burn off a third of the calories they consumed during this day resulting in subjects being in net negative energy balance in this trial
Energy balance
Subjects will consume over a 24 hour period a sufficient amount of calories to meet their energy needs.
Interventions
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Positive energy balance
Subjects will consume over a 24 hour period 33% more calories than they require to meet their energy demands.
Energy balance with exercise
Subjects will consume over a 24 hour period 33% more calories than they require to meet their energy demands but will perform 2 hours of exercise that will be sufficient to burn off the excess calories consumed resulting in subjects being in net energy balance.
Negative energy balance
Subjects will consume over a 24 h period only 66% of the calories required to meet their energy demands such that they will be in a net negative calorie balance in this trial.
Negative energy balance with exercise
Subjects will consume over a 24 hour period the same amount of calories as ingested in the isocaloric trial but will also perform 2 hours of exercise that will be sufficient to burn off a third of the calories they consumed during this day resulting in subjects being in net negative energy balance in this trial
Energy balance
Subjects will consume over a 24 hour period a sufficient amount of calories to meet their energy needs.
Eligibility Criteria
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Inclusion Criteria
* normal to mild hypertriglyceridemia
Exclusion Criteria
* Any medical condition other than increased body weight (e.g. diabetes, heart disease, etc.).
* Use of drugs known to affect lipid metabolism (e.g. statins, etc.).
* Regular exercise training.
21 Years
50 Years
MALE
Yes
Sponsors
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Washington University School of Medicine
OTHER
Responsible Party
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Principal Investigators
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Bettina Mittendorfer, PhD
Role: PRINCIPAL_INVESTIGATOR
Washington University School of Medicine
Locations
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Washington University in Saint Louis
St Louis, Missouri, United States
Countries
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References
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Smith GI, Magkos F, Reeds DN, Okunade AL, Patterson BW, Mittendorfer B. One day of mixed meal overfeeding reduces hepatic insulin sensitivity and increases VLDL particle but not VLDL-triglyceride secretion in overweight and obese men. J Clin Endocrinol Metab. 2013 Aug;98(8):3454-62. doi: 10.1210/jc.2013-1786. Epub 2013 Jun 7.
Other Identifiers
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05-0195
Identifier Type: -
Identifier Source: org_study_id
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