Postprandial VLDL-TG Metabolism

NCT ID: NCT01961024

Last Updated: 2017-05-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

21 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-01-31

Study Completion Date

2015-08-31

Brief Summary

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In thise study, we aim to determine the effect of meal fat on VLDL-TG kinetics in type 2 diabetic and healthy subjects matched for BMI in order to elucidate the potential pathophysiological differences in VLDL-TG FA channeling towards oxidation and storage in abdominal and leg subcutaneous adipose tissue. Specifically, we want to measure, by way of fat and muscle biopsies, the quantitative postprandial storage of VLDL-TG FA's in skeletal muscle and adipose tissue in relation to a series of tissue specific proteins and enzymes that might be involved in regulating skeletal muscle and adipose tissue FA storage.

Detailed Description

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Conditions

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Type 2 Diabetes

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Type 2 diabetic men

No interventions assigned to this group

Age- and weight-matched controls

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Written consent

Exclusion Criteria

* Known diseases
* Alcohol abuse
* Smoker
* Regular use of medicine
Minimum Eligible Age

30 Years

Maximum Eligible Age

70 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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University of Aarhus

OTHER

Sponsor Role lead

Responsible Party

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Esben Søndergaard

Post Doc, MD, PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Department of Endocrinology MEA, Aarhus Hospital

Aarhus C, Please Select, Denmark

Site Status

Countries

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Denmark

References

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Sondergaard E, Johansen RF, Jensen MD, Nielsen S. Postprandial VLDL-TG metabolism in type 2 diabetes. Metabolism. 2017 Oct;75:25-35. doi: 10.1016/j.metabol.2017.07.002. Epub 2017 Jul 19.

Reference Type DERIVED
PMID: 28964326 (View on PubMed)

Other Identifiers

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ES-0006

Identifier Type: -

Identifier Source: org_study_id

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