Search for Biological Markers of Orosensory Perception of Fatty Acids in Healthy Subjects and Possible Modifications in Patients With Type 2 Diabetes and in Obese Non-diabetic Patients.
NCT ID: NCT02028975
Last Updated: 2014-01-07
Study Results
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Basic Information
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UNKNOWN
NA
90 participants
INTERVENTIONAL
Brief Summary
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We also aim to determine whether the hormonal response induced by orosensory stimulation by lipids is modified:
* in patients with type 2 diabetes
* in obese non-diabetic patients We expect to show an increase in biological markers biological, and more particularly in certain digestive hormones such as Pancreatic polypeptide, GIP, GLP-1…after stimulation of the lingual lipid receptor, CD36. We will also determine whether or not this response is modified in patients with type 2 diabetes and in obese non-diabetic patients.
We also wish to measure the subjects' gustatory detection threshold for a fatty acid (linoleic acid), and to determine whether there is a relationship between the orosensory perception threshold for linoleic acid and the physiological status of the subjects. In order to achieve this, the thresholds for healthy subjects will be compared with thresholds for obese and diabetic subjects. Expected results: the threshold of detection for linoleic acid in healthy subjects will be lower than that in obese or diabetic patients.
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
NONE
Study Groups
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Patients with type 2 diabetes
Measure the threshold of detection for linoleic acid
Oral stimulation tests
Venous blood samples
Samples for genetic studies (ancillary study)
Obese patients without diabetes
Measure the threshold of detection for linoleic acid
Oral stimulation tests
Venous blood samples
Samples for genetic studies (ancillary study)
Healthy volunteers
Measure the threshold of detection for linoleic acid
Oral stimulation tests
Venous blood samples
Samples for genetic studies (ancillary study)
Interventions
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Measure the threshold of detection for linoleic acid
Oral stimulation tests
Venous blood samples
Samples for genetic studies (ancillary study)
Eligibility Criteria
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Inclusion Criteria
* Healthy volunteers:
* Men \> 18 years
* 19 \<BMI \< 25 kg.m-2
* Fasting triglyceridemia \< 1.50 g/l
* Fasting glycemia \< 1.10 g/l
* Without regular medical treatment
* Patients with type-2 diabetes:
* Men \>18 years
* type 2 diabetes (fasting glycemia \> 7 mmol/l at the diagnosis) treated with diet or diet + oral antidiabetics (metformin, and/or insulinsecretion agents \[hypoglycemic sulphonamides, or glinides\] and/or glitazones and/or acarbose)
* Stable oral antidiabetic treatment for 3 months
* Obese non-diabetic patients:
* Men \> 18 years
* BMI 30 kg.m-2
* Fasting glycemia \< 1.10 g/l
* HbA1c \< 6.0%
* Absence of treatment with hypoglycemic agents (including benfluorex)
* Absence of medical treatment for obesity
* Absence of a history of surgery for obesity (band, by-pass) or gastric stimulator (type Tantalus)
Exclusion Criteria
* Smokers, or smoking cessation within the 3 months preceding inclusion
* Persons with eating disorders:
* Severe digestive disease (enteropathy with absorption disorders, inflammatory digestive disease)
* Pancreatic insufficiency
* History of pancreas surgery
* Type 1 diabetes
* Renal insufficiency
* Hepatic insufficiency
* Treatment with proton pump inhibitors, insulin, GLP-1 analogues, DPP-4 inhibitors
18 Years
ALL
No
Sponsors
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Centre Hospitalier Universitaire Dijon
OTHER
Responsible Party
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Locations
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CHU Dijon
Dijon, , France
Countries
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Central Contacts
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Facility Contacts
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References
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Besnard P, Christensen JE, Bernard A, Simoneau-Robin I, Collet X, Verges B, Burcelin R. Identification of an oral microbiota signature associated with an impaired orosensory perception of lipids in insulin-resistant patients. Acta Diabetol. 2020 Dec;57(12):1445-1451. doi: 10.1007/s00592-020-01567-9. Epub 2020 Jul 16.
Chevrot M, Passilly-Degrace P, Ancel D, Bernard A, Enderli G, Gomes M, Robin I, Issanchou S, Verges B, Nicklaus S, Besnard P. Obesity interferes with the orosensory detection of long-chain fatty acids in humans. Am J Clin Nutr. 2014 May;99(5):975-83. doi: 10.3945/ajcn.113.077198. Epub 2014 Feb 12.
Other Identifiers
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VERGES 2009
Identifier Type: -
Identifier Source: org_study_id
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