Macronutrients and Gut Hormone Secretion

NCT ID: NCT01366794

Last Updated: 2014-03-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

36 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-09-30

Study Completion Date

2013-09-30

Brief Summary

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Study hypothesis is to examine the relative contribution of macronutrients for gut hormone secretion after a mixed meal in healthy volunteers and in subjects with type 2 diabetes. Individual macronutrients or a mixed meal will therefore be served and gut hormones are measured during the following 300 min.

Detailed Description

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In healthy volunteers and subjects with dietary regulated diabetes mellitus, glucose, protein mixture or fat emulsion will be served individually and on a separate occasions a mixed meal will be served. Samples will be taken during the following 300 min. Concentrations of the gut hormones glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1, insulin and glucagon will be determined.

Conditions

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Type 2 Diabetes

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

FACTORIAL

Blinding Strategy

NONE

Study Groups

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Type 2 diabetes

Administration of macronutrients in type 2 diabetes

Group Type EXPERIMENTAL

Macronutrients

Intervention Type OTHER

Glucose 330 kcal Protein 110 kcal Fat emulsion 110 kcal Mixed meal 550 kcal

Healthy volunteers

Administration of macronutrients in healthy volunteers

Group Type EXPERIMENTAL

Macronutrients

Intervention Type OTHER

Glucose 330 kcal Protein 110 kcal Fat emulsion 110 kcal Mixed meal 550 kcal

Interventions

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Macronutrients

Glucose 330 kcal Protein 110 kcal Fat emulsion 110 kcal Mixed meal 550 kcal

Intervention Type OTHER

Other Intervention Names

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Glucose Protein mixture Fat emulsion Mixed meal

Eligibility Criteria

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Inclusion Criteria

* Healthy status or type 2 diabetes with dietary regulation

Exclusion Criteria

* Liver disease
* kidney disease
* thyroid disease
Minimum Eligible Age

35 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Lund University

OTHER

Sponsor Role lead

Responsible Party

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Bo Ahren

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Bo Ahrén, PhD

Role: PRINCIPAL_INVESTIGATOR

Lund University

Locations

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Department of Clinical Sciences Lund, Lund University

Lund, , Sweden

Site Status

Lund University

Lund, , Sweden

Site Status

Countries

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Sweden

Other Identifiers

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005

Identifier Type: -

Identifier Source: org_study_id

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