Nutrigenomics Investigation of the Body's Metabolic Response to 2 Different Meal Challenges
NCT ID: NCT01172951
Last Updated: 2011-01-11
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
200 participants
INTERVENTIONAL
2008-12-31
2010-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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OGTT-OGTT-Physical tests
2 successive Oral Glucose Tolerance Tests followed by a physical tests session
Oral glucose tolerance test
75g anhydrous glucose powder mixed with 100mls water
OLTT-OLTT-Physical tests
2 successive Oral Lipid Tolerance Tests followed by a physical test session
Oral lipid tolerance test
150ml drink composed of 2 commercially available high fat products
OGTT-OLTT-Physical tests
Oral glucose tolerance test followed by an oral lipid tolerance test (or vice-versa) followed by a physical tests session
Oral glucose tolerance test
75g anhydrous glucose powder mixed with 100mls water
Oral lipid tolerance test
150ml drink composed of 2 commercially available high fat products
Interventions
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Oral glucose tolerance test
75g anhydrous glucose powder mixed with 100mls water
Oral lipid tolerance test
150ml drink composed of 2 commercially available high fat products
Eligibility Criteria
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Inclusion Criteria
* Not taking medication (other than contraceptive pill/HRT)
* Irish resident and living in Dublin area
Exclusion Criteria
* Pregnancy/lactation
* Desire to conceive or lose weight during study
* Athlete
18 Years
60 Years
ALL
Yes
Sponsors
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University College Dublin
OTHER
Responsible Party
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Institute of Food and Health, University College Dublin
Principal Investigators
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Michael J Gibney, PhD
Role: PRINCIPAL_INVESTIGATOR
University College Dublin
Donal O'Shea, MD
Role: PRINCIPAL_INVESTIGATOR
St Vincent's University Hospital, Ireland
Helen Roche, PhD
Role: PRINCIPAL_INVESTIGATOR
University College Dublin
Lorraine Brennan, PhD
Role: PRINCIPAL_INVESTIGATOR
University College Dublin
Eileen Gibney, PhD
Role: PRINCIPAL_INVESTIGATOR
University College Dublin
Locations
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Institute for Sport and Health, University College Dublin
Dublin, , Ireland
St Vincent's University Hospital
Dublin, , Ireland
Countries
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References
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Jackson KG, Li Y, Ryan MF, Gibney ER, Brennan L, Roche HM, Williams CM, Lovegrove JA, Vimaleswaran KS. Association of the tumor necrosis factor-alpha promoter polymorphism with change in triacylglycerol response to sequential meals. Nutr J. 2016 Jul 25;15(1):70. doi: 10.1186/s12937-016-0190-9.
Matone A, O'Grada CM, Dillon ET, Morris C, Ryan MF, Walsh M, Gibney ER, Brennan L, Gibney MJ, Morine MJ, Roche HM. Body mass index mediates inflammatory response to acute dietary challenges. Mol Nutr Food Res. 2015 Nov;59(11):2279-92. doi: 10.1002/mnfr.201500184. Epub 2015 Sep 22.
Morris C, O'Grada CM, Ryan MF, Gibney MJ, Roche HM, Gibney ER, Brennan L. Modulation of the lipidomic profile due to a lipid challenge and fitness level: a postprandial study. Lipids Health Dis. 2015 Jul 1;14:65. doi: 10.1186/s12944-015-0062-x.
Ferguson JF, Ryan MF, Gibney ER, Brennan L, Roche HM, Reilly MP. Dietary isoflavone intake is associated with evoked responses to inflammatory cardiometabolic stimuli and improved glucose homeostasis in healthy volunteers. Nutr Metab Cardiovasc Dis. 2014 Sep;24(9):996-1003. doi: 10.1016/j.numecd.2014.03.010. Epub 2014 Apr 18.
Wallace M, Morris C, O'Grada CM, Ryan M, Dillon ET, Coleman E, Gibney ER, Gibney MJ, Roche HM, Brennan L. Relationship between the lipidome, inflammatory markers and insulin resistance. Mol Biosyst. 2014 Jun;10(6):1586-95. doi: 10.1039/c3mb70529c. Epub 2014 Apr 9.
Morris C, Grada CO, Ryan M, Roche HM, De Vito G, Gibney MJ, Gibney ER, Brennan L. The relationship between aerobic fitness level and metabolic profiles in healthy adults. Mol Nutr Food Res. 2013 Jul;57(7):1246-54. doi: 10.1002/mnfr.201200629. Epub 2013 Mar 15.
Ryan MF, O'Grada CM, Morris C, Segurado R, Walsh MC, Gibney ER, Brennan L, Roche HM, Gibney MJ. Within-person variation in the postprandial lipemic response of healthy adults. Am J Clin Nutr. 2013 Feb;97(2):261-7. doi: 10.3945/ajcn.112.047936. Epub 2013 Jan 2.
Morris C, O'Grada C, Ryan M, Roche HM, Gibney MJ, Gibney ER, Brennan L. The relationship between BMI and metabolomic profiles: a focus on amino acids. Proc Nutr Soc. 2012 Nov;71(4):634-8. doi: 10.1017/S0029665112000699. Epub 2012 Aug 6.
Other Identifiers
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DAF- HRB (Ireland)
Identifier Type: OTHER_GRANT
Identifier Source: secondary_id
LS-08-43-GR
Identifier Type: -
Identifier Source: org_study_id
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