The Influence of Overfeeding Different Macronutrients on Whole-body Insulin Sensitivity
NCT ID: NCT03863431
Last Updated: 2021-02-24
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
20 participants
INTERVENTIONAL
2019-05-22
2021-06-30
Brief Summary
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Following habitual diet, participants will be randomly allocated to either a high-carbohydrate or a high-fat diet intervention for 14-days. On days 0, 7 and 14 participants will undergo anthropometric and metabolic testing (primarily an oral glucose tolerance test \[OGTT\]).
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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High-fat diet
Participants will consume a diet rich in fat (approximately 65% of total energy) and low in carbohydrate for 14 days.
Measurements will be made at 0, 7 and 14 days.
High-fat diet
Participants will consume a high fat diet for 14 days with approximately 65% of energy from fat. The diet will also provide an energy excess, at 130% of energy requirements.
Participants will be provided with all of their meals and snacks throughout the study.
High-carbohydrate diet
Participants will consume a diet rich in carbohydrate (approximately 70% of total energy) and low in fat for 14 days.
Measurements will be made at 0, 7 and 14 days.
High-carbohydrate diet
Participants will consume a high fat diet for 14 days with approximately 70% of energy from carbohydrate. The diet will also provide an energy excess, at 130% of energy requirements.
Participants will be provided with all of their meals and snacks throughout the study.
Interventions
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High-fat diet
Participants will consume a high fat diet for 14 days with approximately 65% of energy from fat. The diet will also provide an energy excess, at 130% of energy requirements.
Participants will be provided with all of their meals and snacks throughout the study.
High-carbohydrate diet
Participants will consume a high fat diet for 14 days with approximately 70% of energy from carbohydrate. The diet will also provide an energy excess, at 130% of energy requirements.
Participants will be provided with all of their meals and snacks throughout the study.
Eligibility Criteria
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Inclusion Criteria
* BMI = 18.5-29.9 kg/m2
* Male or female
* Physically active (\> 3 x 30 min moderate exercise per week)
* Non-smoker (including the use of vaporisers and e-cigarettes)
* Healthy (determined by the School's standard health questionnaire)
* No cardiometabolic or inflammatory illness
Exclusion Criteria
* Outside BMI range
* Inactive (\< 3 x 30 min moderate exercise per week)
* Smoker
* Taking medication
* History of cardiometabolic or inflammatory illness
* Vegetarian/ vegan (as the high-fat diet is based on animal fats)
* Other dietary restrictions which prevent consumption of the experimental diet
* Consumption of probiotics within last 3 months (these influence the gut microbiota)
* Participation in another clinical trial
* Those with known or suspected food intolerances, allergies or hypersensitivity
* Women who are known to be pregnant or who are intending to become pregnant over the course of the study
18 Years
40 Years
ALL
Yes
Sponsors
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Loughborough University
OTHER
Responsible Party
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Carl Hulston
Senior Lecturer Nutrition and Metabolism
Principal Investigators
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Carl Hulston, PhD
Role: PRINCIPAL_INVESTIGATOR
Loughborough University
Locations
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School of Sport, Exercise and Health Sciences
Loughborough, Leicestershire, United Kingdom
Countries
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Central Contacts
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Facility Contacts
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Carl Hulston, PhD
Role: primary
Other Identifiers
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R18-P222
Identifier Type: -
Identifier Source: org_study_id
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