Acute Effects of Oral Carbohydrate and Fat Loads on Systemic Microvascular Endothelial Function in Healthy Individuals.
NCT ID: NCT03515460
Last Updated: 2024-03-26
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
60 participants
INTERVENTIONAL
2018-12-10
2023-12-20
Brief Summary
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Detailed Description
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Vascular endothelial dysfunction is one of the earliest findings in the pathophysiology of atherosclerosis and also an important predictor of cardiovascular events. Moreover, it has already been demonstrated that acute oral ingestion of high loads of sugar and fat meals induces transient vascular endothelial dysfunction, which over time could lead to cardiovascular disease.
Thus, the present study aimed at investigating the individual contributions of sugar and fat ingestion on systemic microvascular endothelial reactivity.
Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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sugar oral load
oral ingestion of a high carbohydrate meal
sugar oral load
The individuals will receive a sugar oral load (high sugar meal)
fat oral load
oral ingestion of a high fat meal
fat oral load
The individuals will a receive fat oral load (high fat meal)
sugar and fat oral loads
oral ingestion of a high carbohydrate and fat meal
sugar and fat oral load
The individuals will a receive sugar and fat oral load (high sugar and high fat meal)
Interventions
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sugar oral load
The individuals will receive a sugar oral load (high sugar meal)
fat oral load
The individuals will a receive fat oral load (high fat meal)
sugar and fat oral load
The individuals will a receive sugar and fat oral load (high sugar and high fat meal)
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* overweight and obesity
20 Years
30 Years
ALL
Yes
Sponsors
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National Institute of Cardiology, Laranjeiras, Brazil
OTHER_GOV
Responsible Party
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Eduardo Tibirica, MD, PhD
Senior Researcher, MD, PhD
Principal Investigators
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EDUARDO TIBIRICA, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
National Institute of Cardiology
Locations
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National Institute of Cardiology, Ministry of Health, Brazil
Rio de Janeiro, , Brazil
Countries
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Other Identifiers
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CAAE 86854318.8.0000.5272
Identifier Type: -
Identifier Source: org_study_id
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