Molecular and Hormonal Responses to Diet-Induced Insulin Resistance

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

15 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-03-02

Study Completion Date

2018-05-22

Brief Summary

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This study determined the effect of 7 days of high-fat overfeeding on whole-body glycaemic control, glucose kinetics, skeletal muscle insulin signalling, and markers of skeletal muscle microvascular function in 15 healthy young individuals.

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Detailed Description

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Fifteen healthy, young individuals underwent metabolic testing before and after 7 days of high-fat overfeeding. We determined whole-body glycaemic control, glucose kinetics, skeletal muscle insulin signalling, and markers of skeletal muscle microvascular function. Stable isotope tracers were used to assess the rate of appearance of glucose from the gut, liver glucose output and whole-body glucose disposal. Insulin signalling was determined by Western blotting of skeletal muscle tissue. Microvascular function was assessed through the use of quantitative immunofluorescence microscopy. These measurements were performed both postabsorptively and following the ingestion of 50 grams of glucose + 15 grams of protein.

Conditions

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Healthy

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

15 healthy individuals were assessed before and after consuming a high-fat, high-energy diet for 7 days.

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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High-fat diet

Participants underwent a 7 day high-fat, high-energy diet intervention with metabolic measurements before and after

Group Type EXPERIMENTAL

High-fat, high-energy diet

Intervention Type DIETARY_SUPPLEMENT

Participants consumed a diet that was high in fat and high in energy

Interventions

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High-fat, high-energy diet

Participants consumed a diet that was high in fat and high in energy

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Aged between 18 and 40 years
* Physically active
* Non-smoker
* Not taking any medication known to interfere with the study
* No history of cardiovascular disease or diabetes
* Weight stable for the last 6 months

Exclusion Criteria

* Outside of age range
* Sedentary
* Smoker
* Taking medication known to interfere with the study
* History of cardiovascular disease or diabetes
* Unstable weight within last 6 months

Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes