Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
10 participants
INTERVENTIONAL
2008-10-31
2011-08-31
Brief Summary
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Objective:
1. The contribution of dietary vs endogenous fat sources to lipid overflow in the circulation and to skeletal muscle lipid uptake and storage in obese insulin resistant subjects vs obese insulin sensitive controls.
2. The acute effect of meals with various fatty acid composition ((high saturated (SFA) vs polyunsaturated (PUFA) vs monounsaturated (MUFA)) on skeletal muscle lipid uptake and storage, fatty acid mediated gene expression and postprandial insulin sensitivity in obese insulin resistant subjects.
Study design: single-blind randomized cross-over trial
Study population: obese males (35-70 years) with or without insulin resistance
Intervention:
1. 1 test meal
2. 3 test meals with a different fatty acid composition
Main study parameters/endpoints:
More insight whether dietary fat quality may modulate circulating lipids and skeletal muscle fatty acids handling, and may affect oxidative capacity and lipid storage in parallel to an increased insulin sensitivity.
Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
PREVENTION
SINGLE
Study Groups
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Saturated fatty acid test meal
test meals with various fatty acid compositions
Three different milkshakes with a U13C palmitate tracer added
Monounsaturated fatty acid meal
test meals with various fatty acid compositions
Three different milkshakes with a U13C palmitate tracer added
Polyunsaturated fatty acid meal
test meals with various fatty acid compositions
Three different milkshakes with a U13C palmitate tracer added
Interventions
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test meals with various fatty acid compositions
Three different milkshakes with a U13C palmitate tracer added
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Liver or kidney failure.
* Diseases in which the live expectation is shorter then 5 years.
* The use of experimental medication.
* Diseases/medication use that may have an influence on the glucose tolerance.
* Not to be able to understand the study information.
* Users of fatty acid supplements including fish oils etc.
* Users of high doses of antioxidant vitamins.
* Athletes.
* People on a diet of people that are planning to lose weight.
35 Years
70 Years
MALE
Yes
Sponsors
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Maastricht University Medical Center
OTHER
Responsible Party
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Principal Investigators
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Ellen E Blaak, PhD, Prof
Role: PRINCIPAL_INVESTIGATOR
Maastricht University Medical Centre +
Locations
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Maastricht University Medical Centre +
Maastricht, Limburg, Netherlands
Countries
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References
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Jans A, Konings E, Goossens GH, Bouwman FG, Moors CC, Boekschoten MV, Afman LA, Muller M, Mariman EC, Blaak EE. PUFAs acutely affect triacylglycerol-derived skeletal muscle fatty acid uptake and increase postprandial insulin sensitivity. Am J Clin Nutr. 2012 Apr;95(4):825-36. doi: 10.3945/ajcn.111.028787. Epub 2012 Feb 15.
Other Identifiers
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08-3-030
Identifier Type: -
Identifier Source: org_study_id