Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE1
26 participants
INTERVENTIONAL
2007-02-28
2007-06-30
Brief Summary
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Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
CROSSOVER
PREVENTION
NONE
Study Groups
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Diet 1
High GI; High Carb; High GL
High GL 107
Three meals a day
Diet 2
High GI, Low Carb, Med GL
Medium GL 76
Three meals a day
Diet 3
Low GI, High Carb, Med GL
Medium GL 68
Three meals a day
Diet 4
Low GI, Low Carb, Low GL
Low GL 48
Three meals a day
Interventions
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High GL 107
Three meals a day
Medium GL 76
Three meals a day
Medium GL 68
Three meals a day
Low GL 48
Three meals a day
Eligibility Criteria
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Inclusion Criteria
* Fasting serum glucose
* Fasting serum glucose \< 125 mg/dl
* Free of chronic disease
* Willing to eat only the foods that are provided by the Center during the diet periods
* Willing to abstain from the consumption of alcohol during the diet periods
* Regularly cycling and willing not to become pregnant using birth control (abstinence, barrier methods, partner surgically sterile
* Monophasic birth control (same dose each day)
* Hormone replacement therapy
* Post-menopausal (over 1 year without bleeding)
* Have had partial hysterectomy over the age of 55
* complete hysterectomy at any age
Exclusion Criteria
* Diabetes mellitus
* Renal, hepatic, endocrine, gastrointestinal, hematological or other systemic disease
* Body Mass Index \<25 or \> 35
* History of drug or alcohol abuse in the last year
* For women, pregnancy, breast feeding or postpartum \< 6 months
* History of depression or mental illness requiring treatment or medication within that last 6 months
* Multiple food allergies or significant food preferences or restrictions that would interfere with diet adherence
* Lifestyle or schedule incompatible with the study protocol
* Planned continued use of dietary supplements through the study trial
* Smoking or tobacco use
18 Years
70 Years
ALL
Yes
Sponsors
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General Mills
INDUSTRY
Pennington Biomedical Research Center
OTHER
Responsible Party
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Frank Greenway
Medial Principal Investigator
Principal Investigators
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Frank L Greenway, MD
Role: PRINCIPAL_INVESTIGATOR
Pennington Biomedical Research Center
William Cefalu, MD
Role: STUDY_CHAIR
Pennington Biomedial Research Center
Marlene M Most, PhD, RD
Role: PRINCIPAL_INVESTIGATOR
Pennington Biomedical Research Center
Locations
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Pennington Biomedical Research Center
Baton Rouge, Louisiana, United States
Countries
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References
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Liu AG, Most MM, Brashear MM, Johnson WD, Cefalu WT, Greenway FL. Reducing the glycemic index or carbohydrate content of mixed meals reduces postprandial glycemia and insulinemia over the entire day but does not affect satiety. Diabetes Care. 2012 Aug;35(8):1633-7. doi: 10.2337/dc12-0329. Epub 2012 Jun 11.
Other Identifiers
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PBRC 26026
Identifier Type: -
Identifier Source: org_study_id