Nutritional Metabolomics: the Search for Dietary Exposure Variables

NCT ID: NCT02039596

Last Updated: 2014-01-17

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 53 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2012-09-30
• Study Completion Date: 2013-11-30

Brief Summary

In the post-genomic era, a major challenge for health research is to understand the complex interactions among genetic, environmental and lifestyle factors including dietary intake. Unfortunately, such initiatives are hampered by the lack of accurate dietary intake assessment methods for large studies. The newly emerging field of metabolomics offers unique possibilities to characterize individual food intake, dietary patterns and effects of dietary intervention in large studies. The investigators propose to develop a platform to detect broad metabolomic responses to food intake in controlled trials as well as to use targeted metabolomics approaches to characterize dietary intake in longitudinal studies. Our laboratory has a long history of developing methodology for assessing nutritional status and effects of diet on metabolism. Here, the investigators team up with the Sahlgrenska Academy Core Facility and the Swedish NMR Centre at the University of Gothenburg, that offer modern metabolomics equipment and competence in bioinformatics, and use this in the context of nutrition research. To their knowledge, the investigators are among the first groups in the country to develop skills in metabolomics to assess dietary intake and effects of nutrition on metabolism, and probably the first to use two complementary platforms with both mass-spectrometry and nuclear magnetic spectroscopy. Hence, our methodological results should be useful to nutritional scientists nationally as well as internationally.

Conditions

Nutrition Disorders; Metabolic Disorders

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: SINGLE

Study Groups

vegetarian breakfast

Diet: Vegetarian food items

Group Type: EXPERIMENTAL

Diet

Intervention Type: OTHER

Swedish Breakfast

Diet: Swedish food items

Group Type: EXPERIMENTAL

Diet

Intervention Type: OTHER

English breakfast

Diet: English food items

Group Type: EXPERIMENTAL

Diet

Intervention Type: OTHER

Lacto-vegetarian breakfast

Diet: Lacto-vegetarian food items

Group Type: EXPERIMENTAL

Diet

Intervention Type: OTHER

Swedish omnivore breakfast

Diet: Swedish breakfast with meat items

Group Type: EXPERIMENTAL

Diet

Intervention Type: OTHER

Interventions

Diet

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Body mass index 18.5-30.0
• Age 18-65 years old

Exclusion Criteria

• Medications or tobacco use

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Göteborg University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Anna K Winkvist, PhD

Role: PRINCIPAL_INVESTIGATOR

Univ of Gothenburg, Sweden

Lars H Ellegard, PhD, MD

Role: STUDY_CHAIR

Univ of Gothenburg

Helen M Lindqvist, PhD

Role: STUDY_DIRECTOR

Univ of Gothenburg

Locations

Dept Internal Medicine and Clinical Nutrition, Univ of Gothenburg

Gothenburg, , Sweden

Countries

Sweden

References

Radjursoga M, Lindqvist HM, Pedersen A, Karlsson GB, Malmodin D, Brunius C, Ellegard L, Winkvist A. The 1H NMR serum metabolomics response to a two meal challenge: a cross-over dietary intervention study in healthy human volunteers. Nutr J. 2019 Apr 8;18(1):25. doi: 10.1186/s12937-019-0446-2.

Reference Type: DERIVED

PMID: 30961592 (View on PubMed)

Other Identifiers

2011-20497-84904-38

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

Nutritional Metabolomics AIKN

Identifier Type: -

Identifier Source: org_study_id