Short Chain Fatty Acid Metabolism and Energy Metabolism
NCT ID: NCT01826162
Last Updated: 2015-09-15
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
10 participants
INTERVENTIONAL
2013-04-30
2013-06-30
Brief Summary
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In this placebo controlled, double-blind, randomized crossover pilot study the investigators will validate in overweight/obese healthy male volunteers whether rectal administration of SCFA is a good model for studying the acute metabolic effects of SCFA. For this, it will be investigated if site of administration (in distal or proximal colon) of SCFA differentially affects parameters of substrate and energy metabolism and to test the duration of short-term effects of SCFA administration.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
DOUBLE
Study Groups
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sigmoidoscopy
2 actetate concentrations and 1 placebo are administered in randomized order after clipping a catheter in the proximal colon (sigmoidoscopy)
acetate or placebo infusion
colonoscopy
2 actetate concentrations and 1 placebo are administered in randomized order after clipping a catheter in the distal colon (colonoscopy)
acetate or placebo infusion
Interventions
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acetate or placebo infusion
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* diabetes mellitus
20 Years
50 Years
MALE
Yes
Sponsors
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Top Institute Food and Nutrition
OTHER
Maastricht University Medical Center
OTHER
Responsible Party
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Principal Investigators
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Ellen Blaak, Prof.
Role: PRINCIPAL_INVESTIGATOR
Maastricht University
Locations
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Maastricht University
Maastricht, Limburg, Netherlands
Maastricht University
Maastricht, , Netherlands
Countries
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Other Identifiers
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MEC 11-3-079
Identifier Type: -
Identifier Source: org_study_id
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