Relationship Between Systemic Fatty Acid Availability and Insulin Sensitivity

NCT ID: NCT01452048

Last Updated: 2022-03-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

38 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-09-30

Study Completion Date

2016-05-26

Brief Summary

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The investigators specific aim is to compare the relationship between systemic fatty acid availability and insulin sensitivity in a relatively homogenous population of obese adults. The investigators anticipate 1) greater systemic fatty acid availability will be associated with lower insulin sensitivity and 2) greater systemic fatty acid availability will be associated with greater accumulation of fatty acid intermediates and pro-inflammatory markers.

Detailed Description

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Conditions

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Obesity

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Obese Sedentary Adults, but otherwise healthy

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Body mass index \[BMI\]: 35-45 kg/m2; All women must be pre-menopausal; Non-exerciser (no regularly planned exercise/physical activity)

Exclusion Criteria

* Weight instability ≥ ±5 lbs. in past month; medications known to affect lipid and/or glucose metabolism; Pregnancy or actively breast feeding
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NIH

Sponsor Role collaborator

University of Michigan

OTHER

Sponsor Role lead

Responsible Party

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Jeffrey F Horowitz

Associate Professor, Movement Science, School of Kinesiology

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jeffrey F Horowitz, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

University of Michigan

Locations

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Michigan Clincal Research Unit

Ann Arbor, Michigan, United States

Site Status

Countries

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United States

Other Identifiers

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R01DK077966

Identifier Type: NIH

Identifier Source: secondary_id

View Link

R01 DK077966 - OC

Identifier Type: -

Identifier Source: org_study_id

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