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Lipid, Glycemic, and Insulin Responses to Meals Rich in Different Fatty Acids

NCT ID: NCT00479791

Last Updated: 2007-05-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

11 participants

Study Classification

INTERVENTIONAL

Study Start Date

1997-04-30

Study Completion Date

1999-06-30

Brief Summary

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A meal rich in very-long chain omega-3 fatty acids or oleic acid may lower postprandial insulin levels in comparison to a meal rich in linoleic acid or palmitic acid. A meal rich in very long-chain omega-3 fatty acids may lower postprandial triglyceride levels compared to other fatty acids.

Detailed Description

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Research Design and Methods: Test meals rich in palmitic acid, linoleic acid, oleic acid, and eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and containing 1,000 kcal each were administered in a randomized cross-over design every 3 to 4 days to 11 patients with T2DM. Serum insulin, glucose, and triglycerides concentrations were measured for 360 minutes. All subjects received an isoenergic diet of constant composition throughout the study.

Conditions

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Type 2 Diabetes Mellitus

Keywords

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Type 2 diabetes mellitus Fatty acids Postprandial response Insulin Glucose Triglycerides

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Interventions

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Test meals rich in different fatty acids

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Type 2 diabetes mellitus not on insulin therapy

Exclusion Criteria

* Thyroid, renal, or hepatic disease, uncontrolled hypertension, anemia, history of ketosis
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Texas Southwestern Medical Center

OTHER

Sponsor Role lead

Principal Investigators

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Abhimanyu Garg, MD

Role: STUDY_CHAIR

UT Southwestern Medical Center at Dallas

Locations

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UT Southwestern Medical Center at Dallas

Dallas, Texas, United States

Site Status

Countries

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United States

Other Identifiers

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M01RR000633

Identifier Type: NIH

Identifier Source: org_study_id

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