Role of Dietary Fatty Acids in Fatty Liver and Insulin Resistance
NCT ID: NCT01038102
Last Updated: 2010-07-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
65 participants
INTERVENTIONAL
2009-02-28
2010-04-30
Brief Summary
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Detailed Description
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1. Investigate if substituting saturated fats with polyunsaturated fats reduces steatosis and improves hepatic and/or peripheral insulin action in abdominally obese subjects with type 2 diabetes
2. Investigate if changes of lipogenic enzymes in response to dietary fat intervention are associated with changes in hepatic/peripheral insulin sensitivity or liver fat content
3. Investigate potential mechanism of the effects of dietary fatty acids; e.g. gene expression and lipogenic enzyme activity
Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
NONE
Study Groups
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PUFA diet
Diet high in polyunsaturated (rich in linoleic acid, omega-6) fat (15 E%)
PUFA Diet
Diet high in polyunsaturated (rich in linoleic acid, omega-6) fat (15 E%).
SFA diet
Diet high in saturated fat (15 E%)
SFA diet
Diet high in saturated fat (15E%)
Interventions
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PUFA Diet
Diet high in polyunsaturated (rich in linoleic acid, omega-6) fat (15 E%).
SFA diet
Diet high in saturated fat (15E%)
Eligibility Criteria
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Inclusion Criteria
* sagittal abdominal diameter \>25cm
Exclusion Criteria
* history of serious cardiovascular events
* morbid obesity
* claustrophobia (relative criterion)
30 Years
65 Years
ALL
Yes
Sponsors
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Swedish Council for Working Life and Social Research
OTHER
Uppsala University
OTHER
Responsible Party
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Uppsala University
Principal Investigators
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Ulf Risérus, PhD
Role: PRINCIPAL_INVESTIGATOR
Clinical Nutrition and Metabolism, Dept. of Public Health and Caring Sciences, Uppsala University
Locations
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Uppsala University Hospital, Uppsala Science Park
Uppsala, , Sweden
Countries
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References
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Summers LK, Fielding BA, Bradshaw HA, Ilic V, Beysen C, Clark ML, Moore NR, Frayn KN. Substituting dietary saturated fat with polyunsaturated fat changes abdominal fat distribution and improves insulin sensitivity. Diabetologia. 2002 Mar;45(3):369-77. doi: 10.1007/s00125-001-0768-3.
Yki-Jarvinen H. Fat in the liver and insulin resistance. Ann Med. 2005;37(5):347-56. doi: 10.1080/07853890510037383.
Bjermo H, Iggman D, Kullberg J, Dahlman I, Johansson L, Persson L, Berglund J, Pulkki K, Basu S, Uusitupa M, Rudling M, Arner P, Cederholm T, Ahlstrom H, Riserus U. Effects of n-6 PUFAs compared with SFAs on liver fat, lipoproteins, and inflammation in abdominal obesity: a randomized controlled trial. Am J Clin Nutr. 2012 May;95(5):1003-12. doi: 10.3945/ajcn.111.030114. Epub 2012 Apr 4.
Other Identifiers
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CKFUU-45521
Identifier Type: OTHER_GRANT
Identifier Source: secondary_id
FAS-2008-1364
Identifier Type: -
Identifier Source: org_study_id
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