Free Fatty Acid Induced Insulin Resistance

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

55 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-03-31

Study Completion Date

2019-11-30

Brief Summary

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This study aims to explore time-dependent effects of lipid infusion an intramyocellular lipid metabolites and the induction of impaired insulin signaling.

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Detailed Description

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Increased availability of free fatty acids impairs glucose disposal in young healthy humans. Patients with type 2 diabetes have reduced whole body glucose disposal, increased ectopic lipid deposition in skeletal muscle and the liver and impaired mitochondrial function. Recent studies suggest that lipid metabolites such as diacylglycerol (DAG), ceramides and long-chain acyl-coA represent the active mediators inducing insulin resistance. Possible targets are DAG-sensitive Proteinkinase C (PKC θ, PKC ε) which inhibit the insulin signaling cascade and ceramides which interfere with the insulin signaling cascade at Proteinkinase B/AKT. Prior studies raised controvesial evidence, thus, it is yet unclear, whether DAG or ceramides are the primary agents inducig lipid-induced insulin resistance. Therefore, the current study aims to explore the time course of the appearance of intramyocellular lipid compunds during lipid infusion in parallel assessing markers of impaired insulin action.

Conditions

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Insulin Resistance

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

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lipid infusion in untrained humans

healthy lean humans before and after lipid infusion

Lipovenös lipid infusion

Intervention Type DIETARY_SUPPLEMENT

Lipid enriched infusions will be applied for 2-6 hours.

lipid infusion in athletes

endurance trained atheletes

Lipovenös lipid infusion

Intervention Type DIETARY_SUPPLEMENT

Lipid enriched infusions will be applied for 2-6 hours.

Interventions

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Lipovenös lipid infusion

Lipid enriched infusions will be applied for 2-6 hours.

Intervention Type DIETARY_SUPPLEMENT

Other Intervention Names

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soy oil

Eligibility Criteria

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Inclusion Criteria

* non-diabetic (OGTT), no family history of diabetes, BMI\<30 kg/m2, age: 20-55 years, no medication

For the athletes group additionally:

* VO2max \> 60ml/kg/min for males and VO2max \> 45ml/kg/min for females Active in endurance-exercise activities, 3 times a week for at least 2 years Stable level of training for at least 3 months

Exclusion Criteria

* acute illness within the last 2 weeks, autoimmune diseases, renal insufficiency (creatinine\> 1.5 mg/dl), cardiovascular diseases, anemia (Hb\< 12g/l), donation of blood within the last 4 weeks before the study, thyroid diseases, pregnancy, smoking, night-shift working (disturbed circadian rhythm), defective coagulation or wound healing, cancer, allergy against soja products

Minimum Eligible Age

20 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes