Role of Colonic Short Chain Fatty Acids in Obesity

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

25 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-02-29

Study Completion Date

2013-01-31

Brief Summary

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The excess production of colonic short-chain-fatty-acids (SCFA) has been implicated in the promotion of obesity, but colonic fermentation of dietary-fiber to SCFA may also play a role in preventing diabetes. The investigators aimed to compare the effects of two fermentable fibers (inulin and resistant-starch) on postprandial SCFA, glucose, insulin, free-fatty acids (FFA) and gut hormone responses and to compare the responses in healthy overweight and obese (OWO) vs lean (LN) participants. Methods: Using a randomized, single blind, crossover design, 13 OWO and 12 LN overnight fasted participants were studied on 3 separate occasions. On each day they consumed a 300 mL drink containing 75g glucose (Control) or 75g glucose plus 24g inulin (IN), or 28.2g resistant-starch (RS). A standard lunch was served 4 h after the test drink.

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Detailed Description

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Conditions

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Obesity

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Lean

Participants with body mass index \<=25

Group Type OTHER

Glucose

Intervention Type OTHER

75g glucose

Inulin

Intervention Type OTHER

75g glucose plus 24g inulin

Resistant Starch

Intervention Type OTHER

75g glucose plus 28.2g resistant starch

Overweight

Participants with body mass index \>25

Group Type OTHER

Glucose

Intervention Type OTHER

75g glucose

Inulin

Intervention Type OTHER

75g glucose plus 24g inulin

Resistant Starch

Intervention Type OTHER

75g glucose plus 28.2g resistant starch

Interventions

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Glucose

75g glucose

Intervention Type OTHER

Inulin

75g glucose plus 24g inulin

Intervention Type OTHER

Resistant Starch

75g glucose plus 28.2g resistant starch

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* non-pregnant
* body mass index \>=20 and \<=35

Exclusion Criteria

* history of diabetes mellitus
* history of cardiovascular disease
* history of bowel disease
* history of kidney disease
* history of liver disease
* use of antibiotics within 3 months of enrolment
* unusual dietary habits
* fasting glucose \>6.9mmol/L
* hematocrit below normal range for age and sex

Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes