Exercise Substrate Utilisation and Endurance Performance Following Short-term Manipulation of Dietary Fat Intake

NCT ID: NCT02568592

Last Updated: 2016-05-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

16 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-03-31

Study Completion Date

2016-06-30

Brief Summary

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The capacity to burn fat as fuel for exercise may have important implications for sporting performance, with dietary fat intake positively influencing this ability.

Endurance performance and the ability to burn fat will be measured in women runners following the consumption of 3 diets varying in the amount of fat and carbohydrate.

Detailed Description

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Dietary fat intake positively influences the ability to burn fat during exercise in women but not men, whereas carbohydrate intake negatively influences fat oxidation in both sexes. The independent nature of dietary fat intake as a predictor of the ability to burn fat in women suggests that in conditions of adequate carbohydrate intake providing additional fat may increase fat oxidation in women whereas it does not in men. It is of interest to explore if indeed women are responsive (i.e., increase in fat oxidation) to short-term increases in dietary fat intake induced by overfeeding (adequate carbohydrate) or if as appears to be the case in men reduced carbohydrate intake as typically employed in high-fat, low carbohydrate dietary studies is also a prerequisite for enhancing fat oxidation in women, and whether this translates into a difference in exercise endurance performance.

Conditions

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Dietary Modification

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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High Fat

High Fat - Carbohydrate (20%), Fat (65%), Protein (15%)

Group Type EXPERIMENTAL

High Fat

Intervention Type DIETARY_SUPPLEMENT

High Fat - Carbohydrate (20%), Fat (65%), Protein (15%)

Normal

Normal - Carbohydrate (50%), Fat (35%) and Protein (15%)

Group Type EXPERIMENTAL

Normal

Intervention Type DIETARY_SUPPLEMENT

Normal - Carbohydrate (50%), Fat (35%) and Protein (15%)

Normal + Extra Fat

Normal + Extra Fat - Carbohydrate (50%), Fat (65%), Protein (15%). Carbohydrate and protein intake identical in absolute amounts to NORM (Normal), with an additional 30% extra energy coming from fat.

Group Type EXPERIMENTAL

Normal + Extra Fat

Intervention Type DIETARY_SUPPLEMENT

Normal + Extra Fat - Carbohydrate (50%), Fat (65%), Protein (15%). Carbohydrate and protein intake identical in absolute amounts to NORMAL, with an additional 30% extra energy coming from fat.

Interventions

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High Fat

High Fat - Carbohydrate (20%), Fat (65%), Protein (15%)

Intervention Type DIETARY_SUPPLEMENT

Normal

Normal - Carbohydrate (50%), Fat (35%) and Protein (15%)

Intervention Type DIETARY_SUPPLEMENT

Normal + Extra Fat

Normal + Extra Fat - Carbohydrate (50%), Fat (65%), Protein (15%). Carbohydrate and protein intake identical in absolute amounts to NORMAL, with an additional 30% extra energy coming from fat.

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* BMI \>17.0 \< 25 kg/m2
* Good General Health
* Accustomed to vigorous physical activity
* Run \> 2 times per week
* V̇O2max \>50ml/kg/min
* Weight Stable \> last 6months
* Non Smoker
* Pre-menopausal, and either eumenorrheic and regularly menstruating, or using monophasic hormonal oral contraceptives for \> 3 months.

Exclusion Criteria

* Currently taking part in another scientific/clinical study
* Taking any prescription drug / supplement thought to influence metabolism
* Following unusual dietary practices (such as intermittent fasting or low carbohydrate diets)
* Pregnant
* Breast Feeding
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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GlaxoSmithKline

INDUSTRY

Sponsor Role collaborator

University of Birmingham

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Gareth A Wallis, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Birmingham

Locations

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University of Birmingham

Birmingham, West Midlands, United Kingdom

Site Status

Countries

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United Kingdom

Other Identifiers

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ERN_15-0012

Identifier Type: -

Identifier Source: org_study_id

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