Cardiovascular and Metabolic Responses to a Mixed Meal

NCT ID: NCT00882986

Last Updated: 2015-09-24

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 20 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2009-01-31
• Study Completion Date: 2011-08-31

Brief Summary

The purpose is to determine whether regular endurance exercise and/or body weight influence the way our nervous and vascular systems respond during the metabolism of meals.

Detailed Description

To begin to examine this question we recruited healthy endurance-trained (high fit, HF) and normally active (average fit, AF) subjects. It is well characterized that chronic endurance training results in enhanced peripheral insulin sensitivity. Therefore, our rationale was that inclusion of two healthy subject groups, with distinct differences in insulin sensitivity, would allow us to investigate how enhanced insulin sensitivity influences insulin-mediated changes in central sympathetic outflow. Direct measurements of central sympathetic outflow to skeletal muscle (i.e., MSNA) were recorded, and a mixed meal was used as a physiological method to evoke robust and sustained increases in MSNA, which have been primarily attributed to insulin. We hypothesized that HF subjects would have a greater MSNA response, for a given plasma insulin concentration, following consumption of a mixed meal (i.e., greater central insulin sensitivity).

Conditions

Insulin Resistance

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

1

Men with high fitness (above VO2max of 60)

No interventions assigned to this group

2

Men with average fitness (below VO2max of 50)

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• healthy, not currently taking any medications

Exclusion Criteria

• unhealthy, taking medications

• Minimum Eligible Age: 20 Years
• Maximum Eligible Age: 50 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

John Thyfault

OTHER

Sponsor Role: lead

Responsible Party

John Thyfault

Associate Professor

Responsibility Role: SPONSOR_INVESTIGATOR

Principal Investigators

John P Thyfault, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Kansas Medical Center

Locations

University of Kansas Medical Center

Kansas City, Kansas, United States

Countries

United States

Other Identifiers

1121717

Identifier Type: -

Identifier Source: org_study_id