Training in the Fasted State, Glucose Metabolism and Energy Balance

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-10-31

Study Completion Date

2019-09-30

Brief Summary

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In healthy individuals, the body responds to glucose (sugar) ingestion by reducing the amount released from the liver. At the same time, skeletal muscles increase the rate at which they remove the glucose from the bloodstream, via the actions of the hormone insulin. This ensures that blood glucose levels remain in a controlled range. However, in developed countries, diseases such as metabolic syndrome and type 2 diabetes are becoming prevalent, due to dietary modifications and a reduction in physical activity. As one of the prominent barriers to regular physical activity is a lack of time, finding ways to maximize the health benefits of exercise is a priority for researchers.

The investigators want to understand potential differences in the effects of six weeks of aerobic training, with the exercise performed either after breakfast or after a prolonged fast. Specifically, this research aims to investigate whether there is a difference in the change in processes implicated in glucose regulation and secondly, in subsequent eating and physical activity behaviors. By investigating these changes this work will explore how exercise and nutrition can be optimized to benefit health and weight loss.

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Detailed Description

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Conditions

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Glucose Metabolism Disorders

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Control Group

Maintain habitual habits

Group Type ACTIVE_COMPARATOR

Maintain habitual habits

Intervention Type BEHAVIORAL

Normal physical activity and dietary behaviors maintained

Fed Exercise

6 weeks of moderate intensity exercise with breakfast consumption

Group Type ACTIVE_COMPARATOR

Exercise

Intervention Type BEHAVIORAL

Moderate intensity exercise

Breakfast

Intervention Type BEHAVIORAL

Breakfast consumption

Fasted Exercise

6 weeks of moderate intensity exercise with breakfast omission

Group Type EXPERIMENTAL

Exercise

Intervention Type BEHAVIORAL

Moderate intensity exercise

Interventions

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Exercise

Moderate intensity exercise

Intervention Type BEHAVIORAL

Breakfast

Breakfast consumption

Intervention Type BEHAVIORAL

Maintain habitual habits

Normal physical activity and dietary behaviors maintained

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Male
* Aged 18-49
* Body mass index (BMI) \> 25 kg/m2
* Weight stable for \> 6 months
* Not currently engaging in any form of structured exercise
* Be able and willing to give informed oral and written consent
* Complete and meet the defined criteria of pre-study questionnaires and screen

Exclusion Criteria

* Have a history of metabolic, cardio-pulmonary or musculoskeletal disease
* Have plans to change diet and/or physical activity outside of the intervention
* Taking regular medication or food supplements from which it is not possible to refrain and which are known to influence any of the outcome measures.
* Failure to refrain from alcohol and/or caffeine containing drinks or strenuous exercise one day before or during the trial days
* Smokers
* Any reported condition or behavior deemed to pose a risk to the participant or introduce bias into the experiment

Minimum Eligible Age

18 Years

Maximum Eligible Age

49 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes