Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
15 participants
INTERVENTIONAL
2020-09-01
2021-12-13
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
TREATMENT
NONE
Study Groups
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Cold acclimation arm
An oral glucose tolerance test will be performed on day 1 of the study. The next day (day 2), subjects will be exposed to shivering thermogenesis for at least 1 hour. The day after, an oral glucose tolerance test will be performed (day 3). The following 9 days, subjects will be exposed daily to shivering thermogenesis for at least 1 hour (day 4-12). On the last day (day 13), an oral glucose tolerance test will be performed.
Cold exposure
Subjects will be exposed to shivering thermogenesis for at least 1 hour for 10 days
Interventions
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Cold exposure
Subjects will be exposed to shivering thermogenesis for at least 1 hour for 10 days
Eligibility Criteria
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Inclusion Criteria
* Caucasian
* Healthy (as determined by dependent physician based on medical questionnaire)
* Man, or postmenopausal (defined as at least 1year post cessation of menses) woman
* Aged 40 - 75 years at the start of the study
* BMI 27 and 35 kg/m2
* Stable dietary habits (no weight loss or gain \>3kg in the past 3 months)
* Medication use known to hamper subject's safety during study procedures
* Co-morbidities to which the intervention or program that may pose as a complicating factor
* Subjects diagnosed with cardiovascular diseases or cancer
* Fasting plasma glucose ≥ 7.0 mmol/l
* Haemoglobin \< 7.8 mmol/l for women, or \< 8.4 mmol/l for men
* Previously diagnosed with type 2 diabetes
* Abuse alcohol/drug abuse
* Subjects who do not want to be informed about unexpected medical findings during the screening/study or do not wish that their physician is informed.
* Engagement in structured exercise \> 2h per week
* Participation in another biomedical study within 1 month before the first study
* Smoking
* Cold-acclimated, such as takes daily extended cold baths, works in a refrigerated environment, or regular cold-water swimming within 1 month of starting the study
40 Years
75 Years
ALL
No
Sponsors
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Maastricht University
OTHER
Responsible Party
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Principal Investigators
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Wouter van Marken Lichtenbelt, Prof.
Role: PRINCIPAL_INVESTIGATOR
Maastricht University
Locations
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Maastricht University
Maastricht, Limburg, Netherlands
Countries
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References
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Sellers AJ, van Beek SMM, Hashim D, Baak R, Pallubinsky H, Moonen-Kornips E, Schaart G, Gemmink A, Jorgensen JA, van de Weijer T, Kalkhoven E, Hooiveld GJ, Kersten S, Hesselink MKC, Schrauwen P, Hoeks J, van Marken Lichtenbelt WD. Cold acclimation with shivering improves metabolic health in adults with overweight or obesity. Nat Metab. 2024 Dec;6(12):2246-2253. doi: 10.1038/s42255-024-01172-y. Epub 2024 Dec 6.
Other Identifiers
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NL73487.068.20
Identifier Type: -
Identifier Source: org_study_id
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