Postprandial Effects of Mixed Herbs and Spices on Pathways Associated With Glucose Homeostasis and Inflammation on PBMCs of Healthy Subjects

NCT ID: NCT02931643

Last Updated: 2018-06-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

18 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-10-31

Study Completion Date

2016-12-31

Brief Summary

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This study aims to investigate the effect of mixed of herbs and spices on gene expression of pathways associated with glucose homeostasis, oxidative stress, inflammation and its interrelation with circulating miRNA, in the postprandial phase in healthy human subjects.

Detailed Description

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Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

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High fat challenge breakfast

High fat breakfast without mixed-spices (% Energy Carbohydrate:Fat:Prot / 20:60:20), acute study / one time administration

Group Type PLACEBO_COMPARATOR

High fat challenge breakfast

Intervention Type OTHER

In this intervention, subjects are asked to consume high fat breakfast without mixed-spices. Standardized high fat breakfast corresponding to % Energy of Carbohydrate:Fat:Prot / 20:60:20

High fat challenge breakfast with mixed-spices

High fat breakfast with mixed-spices (% Energy Carbohydrate:Fat:Prot / 20:60:20), acute study / one time administration

Group Type EXPERIMENTAL

High fat challenge breakfast with mixed-spices

Intervention Type OTHER

In this intervention, subjects are asked to consume high fat breakfast with mixed-spices. Standardized high fat breakfast corresponding to % Energy of Carbohydrate:Fat:Prot / 20:60:20

Interventions

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High fat challenge breakfast

In this intervention, subjects are asked to consume high fat breakfast without mixed-spices. Standardized high fat breakfast corresponding to % Energy of Carbohydrate:Fat:Prot / 20:60:20

Intervention Type OTHER

High fat challenge breakfast with mixed-spices

In this intervention, subjects are asked to consume high fat breakfast with mixed-spices. Standardized high fat breakfast corresponding to % Energy of Carbohydrate:Fat:Prot / 20:60:20

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Healthy males and females
* BMI 23-33 kg/m2
* Must be able to accept spices
* Agreed and signed informed consent

Exclusion Criteria

* Below 18 years old
* Uncomfortable speaking English and/or difficulties in understanding spoken English
* Smoking or using snuss
* Vegetarian or vegan
* Having food allergies
* Stressed by venous blood sampling or previous experience of being difficult to be cannulated
* Receiving any drug treatment that may influence the study outcomes
* Pregnancy or breastfeeding
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Anti-Diabetic Food Centre

OTHER

Sponsor Role collaborator

Lund University

OTHER

Sponsor Role lead

Responsible Party

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Yoghatama Cindya Zanzer

MSc

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Yoghatama Cindya Zanzer, MSc PhDcand

Role: PRINCIPAL_INVESTIGATOR

Lund University

Elin Östman, PhD A/Prof

Role: PRINCIPAL_INVESTIGATOR

Lund University

Congyu Xue, BSc

Role: STUDY_CHAIR

Lund University

Locations

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Food for Health Science Centre, Lund University

Lund, Skåne County, Sweden

Site Status

Countries

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Sweden

Related Links

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http://portal.research.lu.se/portal/sv/projects/antidiabetic-food-centre(3a9bae87-b64a-49f5-97a4-868a8bb776ae).html

Antidiabetic Food Centre - VINNOVA Excellence Centre in Research and Innovation at Lund University, SWEDEN

Other Identifiers

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LUND-AFCSTAGE4-SPICEMULTIOMICS

Identifier Type: -

Identifier Source: org_study_id

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