Effect of Medical Interventions in Insulin Resistance on Prevalence of Abnormal Glucose Tolerance
NCT ID: NCT02502344
Last Updated: 2016-07-21
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE4
60 participants
INTERVENTIONAL
2015-08-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
NONE
Study Groups
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medical intervention group
subjects in this group will accept healthy lifestyle changes such as food control and intensive exercise for 3 months first. Then their insulin resistance will be evaluated again . If their insulin resistance didn't improve, then they will take metformin 0.5g qd to reduce insulin resistance. If their insulin resistance improved, they will continued healthy lifestyle changes.
healthy lifestyle
food control and intensive exercise to lose weight
Metformin
use metformin to reduce insulin resistance
clinical observeral group
subjects in this group will not accept medical interventions
No interventions assigned to this group
Interventions
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healthy lifestyle
food control and intensive exercise to lose weight
Metformin
use metformin to reduce insulin resistance
Eligibility Criteria
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Inclusion Criteria
* diagnosis of insulin resistance
Exclusion Criteria
* function impairment of heart, liver or kidney
20 Years
35 Years
ALL
No
Sponsors
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Beijing Tsinghua Chang Gung Hospital
OTHER
Responsible Party
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Principal Investigators
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Jian Z Xiao, Doctor
Role: STUDY_DIRECTOR
Beijing Tsinghua Changgeng Hospital
Locations
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BEI JING Tsinghua Changguang Hospital
Beijing, Beijing Municipality, China
Countries
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Central Contacts
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Facility Contacts
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References
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Ferrannini E, Mari A. beta-Cell function in type 2 diabetes. Metabolism. 2014 Oct;63(10):1217-27. doi: 10.1016/j.metabol.2014.05.012. Epub 2014 Jun 11.
Weir GC, Bonner-Weir S. Five stages of evolving beta-cell dysfunction during progression to diabetes. Diabetes. 2004 Dec;53 Suppl 3:S16-21. doi: 10.2337/diabetes.53.suppl_3.s16.
Samuel VT, Shulman GI. Mechanisms for insulin resistance: common threads and missing links. Cell. 2012 Mar 2;148(5):852-71. doi: 10.1016/j.cell.2012.02.017.
Li G, Zhang P, Wang J, Gregg EW, Yang W, Gong Q, Li H, Li H, Jiang Y, An Y, Shuai Y, Zhang B, Zhang J, Thompson TJ, Gerzoff RB, Roglic G, Hu Y, Bennett PH. The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up study. Lancet. 2008 May 24;371(9626):1783-9. doi: 10.1016/S0140-6736(08)60766-7.
Other Identifiers
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12015C1023
Identifier Type: -
Identifier Source: org_study_id
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