Effect of Low Glycemic Index Diet on Body Composition and Mechanism of Obese Women

NCT ID: NCT01255228

Last Updated: 2010-12-07

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 20 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2010-05-31
• Study Completion Date: 2011-04-30

Brief Summary

Excessive body weight and obesity have reached epidemic proportions over the last few decades, which may cause many chronic diseases. Maintaining a healthy life style could decrease the risk for obesity, metabolic syndrome and cardiovascular disease. The study aimed to evaluate long-term low glycemic index (GI) diet intervention on lipid profile, body composition and the mechanism of obese women. The pilot study will recruit twenty healthy subjects, and served test food to determine low GI food. In the experiment period, twenty women age from 20-50 years will be recruited. To be included in the study, subjects should have a BMI above 24 kg/m2, or the either one (fat mass ≧ 30% or waistline > 80 cm). Before dietary intervention, participants will receive food choice table and dietary questionnaires to record their dietary intake.

The study will be a randomized, crossover, controlled clinical trails. The experiment period have six weeks, each participants will provide low GI diet (lunch and dinner). On the 0, 3, 6 week, subjects will measurement their body composition (body weight, body mass, waist and hip circumferences) and collect fasting blood samples to analysis the lipid profile, free fatty acid, blood sugar, insulin, adiponectin, leptin and fatty acid synthesis enzymes. Statistical analysis will be performed by paired t-test. The study expect that long-term low GI diet intervention have beneficial effects on regulate body composition of obese women.

Conditions

Obesity

Keywords

obesity; body composition; adipocyte-derived cytokine; low glycemic index

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: HEALTH_SERVICES_RESEARCH
• Blinding Strategy: NONE

Study Groups

Low glycemic index diet

The study expect that long-term low GI diet intervention have beneficial effects on regulate body composition of obese women

Group Type: EXPERIMENTAL

Low glycemic index diet

Intervention Type: OTHER

The study expect that long-term low GI diet intervention have beneficial effects on regulate body composition of obese women

diet intervention

The study expect that long-term low GI diet intervention have beneficial effects on regulate body composition of obese women

Group Type: EXPERIMENTAL

Low glycemic index diet

Intervention Type: OTHER

The study expect that long-term low GI diet intervention have beneficial effects on regulate body composition of obese women

Interventions

Low glycemic index diet

The study expect that long-term low GI diet intervention have beneficial effects on regulate body composition of obese women

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• BMI above 24 kg/m2, or the either one ( fat mass ≧ 30% or waistline > 80 cm )

Exclusion Criteria

• Cardiovascular disease
• type 2 diabetes mellitus or impaired glucose tolerance
• serious liver or renal disease, gastro-intestinal disease
• proceed serious diet control for formerly three months
• take any supplemental food products or medications known to influence lipid or carbohydrate metabolism

• Minimum Eligible Age: 20 Years
• Maximum Eligible Age: 50 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: Yes

Sponsors

Taipei Medical University WanFang Hospital

OTHER

Sponsor Role: lead

Responsible Party

Taipei Medical University, School of Nutrition and Health Sciences

Principal Investigators

Jen-Fang Liu

Role: PRINCIPAL_INVESTIGATOR

Taipei Medical University

Locations

Taipei Medical University

Taipei, , Taiwan

Countries

Taiwan

Other Identifiers

99055

Identifier Type: -

Identifier Source: org_study_id