The Effects of Light on Glucose Metabolism

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

14 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-07-13

Study Completion Date

2020-02-07

Brief Summary

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This study evaluates the effect of bright light on postprandial blood glucose metabolism in obese subjects with impaired fasting glucose and/or impaired glucose tolerance.

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Detailed Description

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Light has a major influence on the biological clock and several studies suggest that bright light during the day and dim light in the evening are beneficial for the circadian timing system. Nowadays, large parts of the population spend 90% of their time indoors and are thereby exposed to artificial lighting instead of daylight. The artificial light levels are relatively low during the day and continue relatively late in the evening. The lack of a clear natural light-dark cycle could results in delayed timing of the biological clock relative to the behaviour. Optimizing the lighting conditions under controlled laboratory settings might lead to better alignment of the biological clock, which in turn could improve metabolic parameters such as glucose control.

Conditions

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Diabetes Mellitus, Type 2 Glucose Intolerance Prediabetic State

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Crossover Assignment

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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dim light during the day

Participants will be exposed to dim light (10 lux) between 8:00 and 18:00 and to dim light (1250 lux) between 18:00 and 23:00.

Group Type EXPERIMENTAL

Exposure to dim light during the day

Intervention Type BEHAVIORAL

Participants will be exposed to dim light (10 lux) between 8:00 and 18:00 and to dim light (1250 lux) between 18:00 and 23:00.

bright light during the day

Participants will be exposed to bright light (1250 lux) between 8:00 and 18:00 and to dim light (5 lux) between 18:00 and 23:00.

Group Type EXPERIMENTAL

Exposure to bright light during the day

Intervention Type BEHAVIORAL

Participants will be exposed to bright light (1250 lux) between 8:00 and 18:00 and to dim light (5 lux) between 18:00 and 23:00.

Interventions

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Exposure to bright light during the day

Participants will be exposed to bright light (1250 lux) between 8:00 and 18:00 and to dim light (5 lux) between 18:00 and 23:00.

Intervention Type BEHAVIORAL

Exposure to dim light during the day

Participants will be exposed to dim light (10 lux) between 8:00 and 18:00 and to dim light (1250 lux) between 18:00 and 23:00.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Caucasian
* BMI 25-35 kg/m2
* Stable weight (+/- 3 kg in the last 3 months)
* One of the four criteria for prediabetes:

* Impaired fasting glucose (6.1 mM to 6.9 mM)
* Blood glucose values 7.8 - 11.1 mM 2h after glucose drink consumption during the oral glucose tolerance test (OGTT) in screening
* Insulin Resistance: glucose clearance rate ≤ 360 ml/kg/min, as determined using the oral glucose insulin sensitivity (OGIS120) index
* HbA1c of 5.7 - 6.4%.

Exclusion Criteria

* Fasting plasma glucose ≥7.0 mM
* Blood donation one month prior to study and three months after finishing study.
* Participants with extreme chronotypes (going to bed extremely late/early).

Minimum Eligible Age

40 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes