Cardiorespiratory Responses to Treadmill Running at Different Slopes

NCT ID: NCT03946215

Last Updated: 2025-10-01

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 8 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2018-09-01
• Study Completion Date: 2018-12-17

Brief Summary

The purpose of this study is: i) to determine if maximal oxygen uptake in downhill running is significantly different versus flat or uphill running, and ii) to compare cardiorespiratory and muscle fatigue responses to uphill vs flat and downhill running at similar running velocity and similar metabolic power. The investigators hypothesized that maximal oxygen uptake will be lower in downhill running. The investigators also anticipate attenuated cardiorespiratory and muscle fatigue responses to downhill running when compared to flat or uphill running performed at similar velocity but not when the comparison is done at similar metabolic power.

Conditions

Cardiorespiratory Responses; Well-trained Athletes

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: HEALTH_SERVICES_RESEARCH
• Blinding Strategy: NONE

Study Groups

well-trained athletes

A cardiorespiratory stress test

Group Type: EXPERIMENTAL

Each participant will perform:

Intervention Type: OTHER

Part 1: Maximal incremental tests will require running at fixed slopes (+15%, 0% -15%) for stages (2min duration) of increasing velocities (0.5, 1 and 1.5 km/h) Part two: submaximal running tests will require running at constant velocity (80% VO2max uphill; 80%VO2max downhill and downhill at similar velocity as uphill)

Interventions

Each participant will perform:

Part 1: Maximal incremental tests will require running at fixed slopes (+15%, 0% -15%) for stages (2min duration) of increasing velocities (0.5, 1 and 1.5 km/h) Part two: submaximal running tests will require running at constant velocity (80% VO2max uphill; 80%VO2max downhill and downhill at similar velocity as uphill)

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• to be a well-trained runner with a VO2max > à 55 ml/kg/min
• nonsmoker or stopped smoking for 5 years
• BMI < 25
• affiliation to the social health insurance scheme
• signing an informed consent form.

Exclusion Criteria

• impossibility to give the subject enlightened information (subject in emergency situation, difficulties in understanding the study, ...);
• subject under the protection of justice
• subject under guardianship or curatorship
• contraindication to the practice of physical and sport activities
• lower limbs musculotendinous or articular problems
• respiratory, cardiovascular or metabolic pathology
• drug treatment in progress and impossibility to stop it within 7 days before the beginning of the study

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

University Hospital, Strasbourg, France

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Les Hôpitaux Universitaires de Strasbourg

Strasbourg, , France

Countries

France

References

Lemire M, Hureau TJ, Remetter R, Geny B, Kouassi BYL, Lonsdorfer E, Isner-Horobeti ME, Favret F, Dufour SP. Trail Runners Cannot Reach V O2max during a Maximal Incremental Downhill Test. Med Sci Sports Exerc. 2020 May;52(5):1135-1143. doi: 10.1249/MSS.0000000000002240.

Reference Type: BACKGROUND

PMID: 31815832 (View on PubMed)

Other Identifiers

7038

Identifier Type: -

Identifier Source: org_study_id