Evaluation of Arginine in Periodontal and Cardiovascular Disease
NCT ID: NCT03873948
Last Updated: 2019-10-04
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
141 participants
OBSERVATIONAL
2014-01-06
2019-03-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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CASE_CROSSOVER
CROSS_SECTIONAL
Study Groups
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Control
Healthy patients
Evaluation of arginine serum level
correlation of serum arginine level with periodontal and cardiovascular disease
Periodontitis
Patients with periodontal disease
Evaluation of arginine serum level
correlation of serum arginine level with periodontal and cardiovascular disease
Cardiovascular
Patients with cardiovascular disease
Evaluation of arginine serum level
correlation of serum arginine level with periodontal and cardiovascular disease
Periodontitis+Cardiovascular
Patients with both periodontal and cardiovascular disease
Evaluation of arginine serum level
correlation of serum arginine level with periodontal and cardiovascular disease
Interventions
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Evaluation of arginine serum level
correlation of serum arginine level with periodontal and cardiovascular disease
Eligibility Criteria
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Inclusion Criteria
* CP with a minimum of 40% of sites with a clinical attachment level (CAL) ≥2mm and probing depth (PD) ≥4mm;
* Presence of at least ≥2 mm of crestal alveolar bone loss verified on digital periapical radiographs
* Presence of ≥40% sites with bleeding on probing (BOP)
Exclusion Criteria
* Intake of immunosuppressive or anti-inflammatory drugs throughout the last three months prior to the study
* Status of pregnancy or lactation
* Previous history of excessive drinking
* Allergy to local anaesthetic
* Intake of drugs that may potentially determine gingival hyperplasia such as Hydantoin, Nifedipine, Cyclosporin A or similar drugs.
19 Years
75 Years
ALL
Yes
Sponsors
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University of Messina
OTHER
Responsible Party
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Gaetano Isola, DDS, PhD
Junior Assistant Professor
Locations
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University of Messina
Messina, , Italy
Countries
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Other Identifiers
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12-16
Identifier Type: -
Identifier Source: org_study_id
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