Serum A.Actinomycetemcomitans Antibodies and Periodontitis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

221 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-04-15

Study Completion Date

2020-03-25

Brief Summary

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The aim of this study was to analyze the association between serum A.actinomycetemcomitans antibodies in patients with periodontitis. Furthermore, the objective was to determine if the periodontitis influenced serum IgG A.actinomycetemcomitans antibodies levels

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Detailed Description

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53 patients with periodontitis and 48 healthy subjects (HS) were enrolled in the present study. Enrolled patients were examined and characterized for clinical and blood samples analysis and A.actinomycetemcomitans antibodies were expressed and evaluated enzyme-linked immunosorbent assay (ELISA) units (EU). The Spearman Correlation Test and Jonckheere-Terpstra Test were applied in order to assess the interdependence between serum IgG A.actinomycetemcomitans antibodies and clinical periodontal parameters.

Conditions

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Periodontal Diseases

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Control

Observation of serum A.actinomycetemcomitans levels and correlation of plasma A.actinomycetemcomitans levels

observation of serum A.actinomycetemcomitans levels

Intervention Type OTHER

Analysis of serum A.actinomycetemcomitans levels

Periodontitis

Observation of serum A.actinomycetemcomitans levels and correlation of plasma A.actinomycetemcomitans levels

observation of serum A.actinomycetemcomitans levels

Intervention Type OTHER

Analysis of serum A.actinomycetemcomitans levels

Interventions

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observation of serum A.actinomycetemcomitans levels

Analysis of serum A.actinomycetemcomitans levels

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Presence of at least 15 teeth
* CP with a minimum of 40% of sites with a clinical attachment level (CAL)

≥2mm and probing depth (PD) ≥4mm;
* Presence of at least ≥2 mm of crestal alveolar bone loss verified on digital periapical radiographs
* Presence of ≥40% sites with bleeding on probing (BOP)

Exclusion Criteria

* Intake of contraceptives
* Intake of immunosuppressive or anti-inflammatory drugs throughout the last three months prior to the study
* Status of pregnancy or lactation
* Previous history of excessive drinking
* Allergy to local anaesthetic
* Intake of drugs that may potentially determine gingival hyperplasia such as Hydantoin, Nifedipine, Cyclosporin A or similar drugs.

Minimum Eligible Age

34 Years

Maximum Eligible Age

72 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes