Impact of Periodontal Bacteria at Baseline on the Effectiveness of Periodontal Therapy

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

102 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-06-05

Study Completion Date

2020-03-15

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

In light of the controversy that are already approved but that however still exists regarding the efficacy and influence of the protocols for the management of Periodontitis, the aim of this study was to evaluate, at 6 months follow-up, the post-treatment clinical parameters and immunological and gingival microbial profiles in patients with periodontitis, treated by either SRP in addition to full mouth scaling or quadrant scaling

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Impact of Periodontal Bacteria on the Effectiveness of Periodontal Therapy

NCT05558293

Periodontitis

COMPLETED NA

Impact of Periodontal Supportive Therapy in Patients With Gingivitis and Periodontitis

NCT06382753

Gingivitis Periodontitis

RECRUITING

Intervention Study of Two Protocols for Non-surgical Treatment of Chronic Periodontitis

NCT02168621

Chronic Periodontitis

UNKNOWN NA

Decontaminant Agent in the Treatment of Chronic Periodontitis

NCT02657096

Chronic Periodontitis

COMPLETED NA

Periodontal Therapy on the Gut Microbiome of Inflammatory Bowel Disease

NCT04790825

Periodontal Diseases IBD Dysbiosis +1 more

UNKNOWN NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

This trial was conducted in accordance with the World Medical Association's Declaration of Helsinki of 1975, and reviewed in 2008. The local ethical committee of the University of Messina approved the study protocol and each patient was carefully informed about the possible inherent risks of the study and provided their informed written consent 102 patients, , aged 27 to 65 (mean age 44.2) were assessed for eligibility. In all subjects, subgingival plaque was acquired from 4 separate proximal sites at 180 days after therapy.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Periodontitis

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Periodontitis quadrant

Patients undergo non surgical quadrant scaling and root planing

Group Type PLACEBO_COMPARATOR

Scaling and root planing

Intervention Type PROCEDURE

Full mouth or quadrant SRP

Periodontitis full mouth

Patients undergo non surgical full mouth scaling and root planing

Group Type ACTIVE_COMPARATOR

Scaling and root planing

Intervention Type PROCEDURE

Full mouth or quadrant SRP

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Scaling and root planing

Full mouth or quadrant SRP

Intervention Type PROCEDURE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

1. good condition of general health,
2. a minimum of 2 teeth for each quadrant with a Pocket Depth (PD) ranging from 4-6 mm,
3. no involvement of the furcation,
4. a minimum of a six teeth per quadrant, respectively.

Exclusion Criteria

1. periodontal therapy during the last 12 months,
2. assumption of antibiotics during the last 6 months,
3. pregnancy,
4. any systemic condition which might affect the effects of the study treatment,
5. previous or current radiation or immunosuppressive therapies,
6. use of mouthwash containing antimicrobials during the previous 3 months,
7. no use of hormonal contraceptives,
8. medication by anti-inflammatory and immunosuppressive drugs,
9. previous history of hard-drinking,
10. smoking,
11. class II and III tooth mobility.

Minimum Eligible Age

30 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes