Chronic Periodontitis Microbiota in Type 2 Diabetes Mellitus Patients
NCT ID: NCT03786133
Last Updated: 2018-12-24
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
40 participants
OBSERVATIONAL
2016-06-10
2016-11-16
Brief Summary
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Detailed Description
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The recruitment for the study sample was performed analysing the medical records of adult patients with chronic periodontitis visited between 2010 and 2016. Eligible patients were subdivided in two balanced groups on the basis of the presence or absence of type 2 diabetes mellitus at the time of the microbiological test.
For each subject, the following data have been collected: age, gender, smoking habits, type of metabolic control of diabetes, duration of diabetes, number of missing teeth.
For each subject, four periodontal sites were studied. Probing pocket depth, sites with bleeding on probing, sites with suppuration and microbiological data were evaluated.
An individual matching on the basis of severity and extension of periodontitis was performed by pairing a diabetic patient with another non-diabetic one with the same degree of severity and extension of the periodontal disease.
Microbiological data of subgingival biofilm were analysed and compared for the examined pathogens: Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Treponema denticola, Fusobacterium nucleatum, Tannerella forsythia.
Differences in genotypes of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans among diabetic and non-diabetic patients were also evaluated.
Conditions
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Keywords
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Study Design
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CASE_CONTROL
RETROSPECTIVE
Study Groups
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type 2 diabetics
Analysis of microbiological tests in chronic periodontitis patients with type 2 diabetes mellitus
Analysis of microbiological tests
Collection and comparison of microbiological data
non-diabetics
Analysis of microbiological tests in chronic periodontitis patients without type 2 diabetes mellitus
Analysis of microbiological tests
Collection and comparison of microbiological data
Interventions
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Analysis of microbiological tests
Collection and comparison of microbiological data
Eligibility Criteria
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Inclusion Criteria
* diagnosis of type 2 diabetes mellitus (only in the test group)
* the presence of at least 12 teeth (except for the third molar)
* belonging to caucasian ethnic group
* age greater than 18 years.
Exclusion Criteria
* history of systemic antibiotics within 3 months prior to the microbiological testing or anti-inflammatory therapy in the month before the visit
* if they were suffering from any other systemic disease except diabetes mellitus (arthritis, ulcerative colitis, Crohn's disease, osteoporosis or osteopenia, HIV infection, hematologic diseases, neoplastic diseases, cardiovascular diseases or pathologies that could potentially interfere with the periodontitis and/or with diabetes)
* mental disorders
* if they had received periodontal treatment in the 6 months before the microbiological test.
18 Years
ALL
No
Sponsors
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University of Bologna
OTHER
Responsible Party
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Marco Montevecchi
Aggregate Professor of Periodontology
Principal Investigators
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Marco Montevecchi, DDS
Role: STUDY_CHAIR
University of Bologna
Locations
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Alma Mater Studiorum - University of Bologna, Department of Biomedical and Neuromotor Sciences, School of Dentistry - Division of Periodontology and Implantology.
Bologna, , Italy
Countries
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References
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Montevecchi M, Valeriani L, Gatto MR, D'Alessandro G, Piana G. Subgingival pathogens in chronic periodontitis patients affected by type 2 diabetes mellitus: a retrospective case-control study. J Periodontal Implant Sci. 2021 Dec;51(6):409-421. doi: 10.5051/jpis.2100180009.
Other Identifiers
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periopathogensdiabetes
Identifier Type: -
Identifier Source: org_study_id