Subgingival Microbiota Following Mechanical Treatment and it's Effect on Peri-implant Sub-mucosa in Periodontitis Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

12 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-04-01

Study Completion Date

2022-03-01

Brief Summary

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The investigators planed to observe the microbiome of an aggressive periodontitis patient, during mechanical treatment, surgery(if indicated) and implant placement. The investigators designed to observe the changes after mechanical treatment.Then, the investigators will compare the sub-mucosa microbiome of implant and the subgingival community. The investigators expected a different community after treatment, and there could be similarity between implant and nature teeth.

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Detailed Description

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Conditions

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Aggressive Periodontitis, Generalized

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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mechanical treatment(mainly scaling and root planing), periodontal surgery(if indicated), implant placement.

The investigators shall follow the regular procedure to these patients.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

1. Subjects were between 18-35 years old and diagnosed with generalized aggressive periodontitis (GAgP) according to the 1999 International Classification of Periodontal Diseases (Armitage 1999);
2. At least 20 teeth in the first appointment and at least 3 teeth(other than first molars and central incisors)with a probing depth(PD) ≥ 6mm, clinical attachment level (CAL)≥5mm;
3. The clinical diagnosis was confirmed by evidence of inter-proximal bone loss on full-mouth periapical radiographs;
4. Family history of aggressive periodontitis.

Exclusion Criteria

1. Uncontrolled systemic conditions including diabetes and hypertension;
2. Pregnant or lactating;
3. Smoking;
4. Received periodontal treatment within the previous 6 months or antibiotic medication during the previous 3 months.

Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No