Transcriptome, Proteome and Microbiome Profile in Periodontal and Peri-implant Diseases
NCT ID: NCT06262035
Last Updated: 2024-10-10
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
30 participants
OBSERVATIONAL
2024-06-15
2030-12-31
Brief Summary
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2. To study the microbiome and biomarker profile associated with periodontitis and peri- implantitis. Patients with defined periodontitis, at two non-adjacent teeth and peri-implantitis at ≥ one implant in function of ≥ one year, will be included in this study to determine the bacteria composition, cytokine profile and inflammatory biomarkers profile. Subjects will undergo a full-mouth examination performed by a calibrated examiner, including assessment of caries, bone abnormalities and infections according to intraoral x-ray, plaque index and pocket probing depth, suppuration, bleeding on probing, alveolar bone loss, and number of teeth. Peri-implant crevicular fluid (PICF), gingival crevicular fluid (GCF), saliva and submucosal/subgingival plaque will be collected.The presence and composition of periodontal and peri-implant plaque samples are investigated.
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Detailed Description
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Conditions
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Study Design
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COHORT
CROSS_SECTIONAL
Interventions
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Periodontitis and Peri-implantitis
Defined periodontitis at ≤ 2 non-adjacent teeth AND Defined peri-implantitis at ≤ 1 implant, in function of at least 1 year.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
Local or systemic use of antibiotics during last 6 months.
18 Years
ALL
No
Sponsors
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Karolinska Institutet
OTHER
Responsible Party
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Tülay Yucel Lindberg
Associate Professor
Principal Investigators
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Tülay Lindberg, Ass.prof
Role: PRINCIPAL_INVESTIGATOR
Karolinska Institutet
Locations
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Aqua Dental Specialistklinik
Stockholm, , Sweden
Countries
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Central Contacts
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Facility Contacts
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Nilminie Rathnayake, Dr
Role: primary
Other Identifiers
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2023-02987-01
Identifier Type: -
Identifier Source: org_study_id
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