Apoptic Biomarkers of Periodontal Disease

NCT ID: NCT00569075

Last Updated: 2017-05-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2006-10-31

Study Completion Date

2009-10-31

Brief Summary

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The goal of this study is to facilitate early diagnosis of gum disease. Proteins associated with cell death will be isolated from gum pockets of diseased and healthy patients and evaluated.

Detailed Description

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Early detection of the progression of periodontitis is difficult because it typically relies on comparisons of clinical measurements made with a calibrated probe and nonstandardized radiographs over time. Both methods detect periodontal breakdown only after it has occurred. Therefore, considerable emphasis has been placed on identifying more specific and sensitive methods to diagnose and detect periodontal disease progression. The overall goal of this project is to determine whether specific apoptosis-associated proteins, specifically fibronectin (FN) fragments, caspase-3, soluble Fas, and soluble Fas ligand, sampled from gingival crevicular fluid (GCF) can be used as markers for periodontal disease progression.

Conditions

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Periodontitis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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High Risk

High risk disease prone population

collection of gingival crevicular fluid

Intervention Type OTHER

GCF samples will be collected at 3 month intervals

Low Risk

Low risk disease population

collection of gingival crevicular fluid

Intervention Type OTHER

GCF samples will be collected at 3 month intervals

Interventions

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collection of gingival crevicular fluid

GCF samples will be collected at 3 month intervals

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Adults over age of 18
* Healthy or diagnosis of periodontitis

Exclusion Criteria

* Active treatment with anti-inflammatory agents such as NSAIDs or steroids and pregnant females
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Michigan

OTHER

Sponsor Role lead

Responsible Party

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University of Michigan

Principal Investigators

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Yvonne Kapila, DDS, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Michigan

Locations

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Michigan Center for Oral Health Research

Ann Arbor, Michigan, United States

Site Status

Countries

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United States

Other Identifiers

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2004-04

Identifier Type: -

Identifier Source: org_study_id

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