Periostin and Non-Surgical Periodontal Treatment

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

90 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-01-31

Study Completion Date

2018-04-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

A total of 90 subjects, 30 patients with chronic periodontitis, 30 with gingivitis and 30 periodontally healthy subjects were included. Patients with periodontal disease received non-surgical periodontal treatment. Gingival crevicular fluid periostin levels were assessed at baseline, at the 6th week and the 3rd month after treatment.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Effect of Non-Surgical Periodontal Treatment on Gingival Crevicular Fluid and Serum Biomarker Levels

NCT06175624

Periodontitis Gingivitis Healthy

COMPLETED NA

Non-surgical Periodontal Treatment and Periostin Levels

NCT05535049

Periodontal Treatment, Cytokines

COMPLETED NA

Bactericidal Permeability Protein Inhibitor and Interleukin-1beta Levels After Non-surgical Periodontal Treatment

NCT06354504

Periodontitis

COMPLETED NA

Effect of Non-surgical Periodontal Therapy on Gingival Crevicular Fluid Interleukin-21 Levels

NCT02861937

Chronic Peridontitis Patients Chronic Gingivitis Healthy

COMPLETED NA

Effect of Periodontal Therapy on Biomarkers in Periodontitis

NCT05005923

Periodontal Health Periodontitis

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Periostin is commonly found in collagen-rich tissues, which is thought to affect the production of collagen fibers. Additionally, periostin is synthesized in tissues exposed to constant mechanical forces such as the periosteum, periodontal ligament, tendon, heart valve and skin. Periostin mediates inflammation and fibrosis during diseases of various organs, including the heart, lung, kidney, skin, liver, skeletal muscle and retina.

This study evaluated periostin levels in gingival crevicular fluid from patients with chronic periodontitis, gingivitis and periodontally healthy as well as the effect of non-surgical periodontal treatment on gingival crevicular fluid periostin levels.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Periodontal Diseases

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Patients with chronic periodontitis

Patients with CP (n=30) had teeth with 30% periodontal bone loss and ≥ 2 non-adjacent sites per quadrant with probing depth (PD) ≥ 5 mm and bleeding on probing.

Group Type EXPERIMENTAL

Non-Surgical Periodontal Treatment

Intervention Type PROCEDURE

Scaling and root planing and polishing with specific curettes were performed to patients and oral hygiene education was provided to each patient.

Patients with gingivitis

Participants with G (n=30) had gingival index ≥ 2 and other inflammation signs.

Group Type EXPERIMENTAL

Non-Surgical Periodontal Treatment

Intervention Type PROCEDURE

Scaling and root planing and polishing with specific curettes were performed to patients and oral hygiene education was provided to each patient.

Participants with periodontal healthy

The H group (n=30) consisted of individuals with no attachment loss, no history of periodontal disease, PD ≤3 mm, and whole-mouth bleeding scores \<10%.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Non-Surgical Periodontal Treatment

Scaling and root planing and polishing with specific curettes were performed to patients and oral hygiene education was provided to each patient.

Intervention Type PROCEDURE

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Initial periodontal therapy

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Clinical diagnosis of chronic periodontitis
* Clinical diagnosis of gingivitis
* Clinical diagnosis of periodontal health

Exclusion Criteria

* have any systemic disease
* to be alcohol consumer
* to receive any periodontal therapy in the past 6 months
* to take any drugs regularly
* to be pregnant and/or lactate

Minimum Eligible Age

20 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes