Low-level Laser Therapy as an Adjunct to Non-surgical Periodontal Treatment

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

15 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-01-01

Study Completion Date

2018-08-30

Brief Summary

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The present study aimed to investigate the effects of low-level laser therapy (LLLT) as an adjunct to non-surgical periodontal treatment (NSPT) on the plasminogen-activating system in Stage 3-4, Grade C periodontitis patients.

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Detailed Description

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Limited data is available regarding the effects of various periodontal treatment protocols on GCF t-PA and PAI-1 levels, and the extent to which LLLT in conjunction with NSPT affects these levels in patients with Stage 3-4, Grade C periodontitis is unknown. Therefore, this study measured standard clinical outcomes and GCF t-PA and PAI-1 levels in patients with Stage 3-4 Grade, C periodontitis in order to assess the use of LLLT as an adjunct to standard NSPT.

This split-mouth study was conducted with 15 Stage 3-4, Grade C periodontitis patients and 15 healthy individuals matched for age and sex. Participants were grouped as follows: Periodontitis/NSPT (Sham); Periodontitis/NSPT+LLLT (LLLT); Periodontally Healthy (Control). LLLT was applied following NSPT and again on post-treatment Days 2 and 7. Clinical parameters were recorded at baseline (i.e. before NSPT) and on Day 30. Gingival crevicular fluid (GCF) samples were collected at baseline and during follow-up visits on Days 7, 14 and 30. GCF t-PA and PAI-1 levels were measured with ELISA.

Conditions

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Periodontal Diseases Periodontal Attachment Loss Periodontal Disease, AVDC Stage 3 Periodontal Inflammation Periodontal Disease, AVDC Stage 4

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

a split-mouth randomized controlled clinical study

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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non-surgical perıodontal treatment

Group Type SHAM_COMPARATOR

non-surgical periodontal treatment

Intervention Type PROCEDURE

standart periodontal therapy

non-surgical treatment+ low level laser therapy

Group Type EXPERIMENTAL

low level laser therapy

Intervention Type PROCEDURE

adjunctive application of low level laser therapy to non-surgical periodontal treatment

non-surgical periodontal treatment

Intervention Type PROCEDURE

standart periodontal therapy

Interventions

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low level laser therapy

adjunctive application of low level laser therapy to non-surgical periodontal treatment

Intervention Type PROCEDURE

non-surgical periodontal treatment

standart periodontal therapy

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Stage 3-4, Grade C periodontitis (at least one site with probing depth (PD) and clinical attachment level (CAL) ≥5 mm in their incisors and/or first molars and at least 6 other teeth with similar PD and CAL measurements, with alveolar bone loss confirmed by radiography; familial aggregation;
* presence of ≥16 teeth;
* no periodontal treatment in the 6 months prior to data collection;
* non-smoker

Exclusion Criteria

* systemic problems, including a medical history of cancer, rheumatoid arthritis, diabetes mellitus, or cardiovascular disease;
* compromised immune system;
* pregnancy, menopause, or lactation;
* ongoing drug therapy that might affect the clinical characteristics of periodontitis;
* use of systemic antimicrobials during the 6 weeks prior to data collection

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes