Diode Laser-Assisted Periodontal Therapy Enhances Clinical Outcomes for Deep Periodontal Pockets in Smokers

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

33 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-12-10

Study Completion Date

2025-06-05

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study investigated the adjunctive effects of diode laser therapy in smokers with severe periodontitis. Thirty-three patients were randomized to non-surgical periodontal therapy (SRP) with or without diode laser. Clinical parameters and salivary oxidative stress markers (MDA, 8-OHdG) were assessed at baseline, 1, and 3 months. Both groups showed improvements, but SRP+DL resulted in significantly greater reductions in deep pockets, PISA, PESA, PI, and MDA at 3 months. These findings suggest that diode laser therapy may enhance conventional treatment by improving clinical outcomes and reducing oxidative stress in smokers with severe periodontitis.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Diode Laser and SRP in Chronic Periodontitis

NCT02407379

Periodontitis

COMPLETED NA

Diode Laser Study for Periodontal Maintenance Patients

NCT01215201

Periodontal Diseases Periodontitis, Apical, Chronic Nonsuppurative Suppuration of Gingival Crevice

COMPLETED NA

Periodontal Treatment With Diode Laser in the Patients With Diabetes Melitus

NCT03444363

Diabetes Mellitus Periodontal Disease

COMPLETED NA

The Effectiveness of Root Planing and Injectable Platelet-Rich Fibrin in Smoking Patients With Periodontitis

NCT07049549

Periodontal Healing Periodontitis i-PRF

COMPLETED NA

Use of Dual-light Photodynamic Therapy as an Adjunct to Periodontal Treatment in Smokers

NCT05962801

Periodontitis Dual- Light Photodynamic Therapy Smoking, Cigarette +1 more

UNKNOWN NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Periodontitis Periodontitis Stage III Periodontal Disease Diode Laser Therapy Smoking Malondialdehyde

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

To ensure allocation concealment and maintain the masked design, the following protocol was applied: After diagnosis at the Department of Oral Diagnosis and Radiology, baseline periodontal records and anamnesis were documented, and each patient was assigned a unique ID. Eligible participants underwent baseline clinical measurements (D.İ.A) and saliva sampling. Patients were then randomly allocated to SRP (n=17) or SRP+DL (n=16) using a computer-generated program (Sealed Envelope Ltd.) by an independent clinician not involved in the study. One week later, SRP and diode laser procedures were performed by the same clinician (D.İ.A). For blinding, all clinical files were anonymized and coded by the study supervisor (S.S.H). Statistical analyses were conducted by a blinded statistician without access to group assignments.

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Stage III Grade C :Non surgical periodontal therapy and an adjunct diode laser use

Group Type EXPERIMENTAL

Diode Laser Application in Deep Periodontal Pockets

Intervention Type DEVICE

A 940 nm indium-gallium-aluminum-phosphate diode laser (Ezlase, Biolase, USA) with a 400 μm fiber was used in contact mode at 1.5 W, pulse 20/20 ms, 20 s/cm², power density 1.061 W/cm², and 15 J/cm² energy in deep periodontal pockets.

Professional Mechanical Plaque Removal

Intervention Type PROCEDURE

Professional mechanical removal of supragingival plaque and calculus

Scaling and Root Planing

Intervention Type PROCEDURE

Subgingival scaling and root planing

Stage III Grade C :Non surgical periodontal therapy

Group Type EXPERIMENTAL

Professional Mechanical Plaque Removal

Intervention Type PROCEDURE

Professional mechanical removal of supragingival plaque and calculus

Scaling and Root Planing

Intervention Type PROCEDURE

Subgingival scaling and root planing

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Diode Laser Application in Deep Periodontal Pockets

A 940 nm indium-gallium-aluminum-phosphate diode laser (Ezlase, Biolase, USA) with a 400 μm fiber was used in contact mode at 1.5 W, pulse 20/20 ms, 20 s/cm², power density 1.061 W/cm², and 15 J/cm² energy in deep periodontal pockets.

Intervention Type DEVICE

Professional Mechanical Plaque Removal

Professional mechanical removal of supragingival plaque and calculus

Intervention Type PROCEDURE

Scaling and Root Planing

Subgingival scaling and root planing

Intervention Type PROCEDURE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* no periodontal treatment within the previous 6 months;
* no use of antibiotics within the previous 3 months;
* no systemic disease and alcohol drinkers, or drug users;
* no use of anti-inflammatory drugs within the past 3 months;
* no pregnancy;
* no use of hormonal contraceptives; and
* current smokers with a history of smoking ≥10 cigarettes per day for at least one year.

Exclusion Criteria

* Patients with \<20 teeth, grade III tooth mobility, partial dentures, or fixed prostheses were excluded. Additionally, those with dental implants or peri-implant diseases were also excluded.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes